MicroRNA-mediated hypoxia vs cancer (2)

Viruses in anaerobic bacteria thrive via replication in hypoxic conditions. Oxygen helps to biophysically constrain viral replication in aerobic bacteria.

Oxygen does not create itself. The Creation of sunlight and water (Darwin’s “conditions of life”) come before the Creation of oxygen, which typically biophysically constrains nearly all pathology in the context of RNA interference.

See:  Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See for comparison: Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication 10/31/19

These findings point to important mechanisms that contribute to parental nucleosome segregation to preserve cellular identity.

The “…mechanisms that contribute to parental nucleosome segregation to preserve cellular identity.” are energy-dependent and microRNA-mediated in the context of the physiology of reproduction across kingdoms.

The energy comes from sunlight and/or from food.

See: Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus 3/26/19 from Critical Reviews in Food Science and Nutrition Volume 59, 2019 – Issue 6: Bioactive phytochemicals- A companion special issue to the ‘3rd International Symposium on Phytochemicals in Medicine and Food (3-ISPMF, August 25-29 2018,

The role that bioactive phytochemicals play in human healthy longevity has been placed into the context thyroid function.

See:  Combined quantitation of HMGA2 mRNA, microRNAs, and mitochondrial-DNA content enables the identification and typing of thyroid tumors in fine-needle aspiration smears (Russia) 10/28/19

A minimum set of markers was selected (levels of HMGA2 mRNA and miR-375, − 221, and -146b in combination with the mitochondrial-to-nuclear DNA ratio) and yielded highly accurate discrimination (sensitivity = 0.97; positive predictive value = 0.98) between goiters with benign tumors and malignant tumors and accurate typing of papillary, medullary, and Hürthle cell carcinomas. The results support an alternative classification of follicular tumors, which differs from the histological one.

Histological classifications have typically linked mutations to the cause of pathology to mutations. All serious scientists know that 1) the virus-driven degradation of messenger RNA causes the mutations, 2) that prevention is energy-dependent, and 3) that the energy comes from sunlight.

See also 1) The Computational Analysis Conducted on miRNA Target Sites in Association with SNPs at 3’UTR of ADHD-Implicated Genes (Iran) 10/13/19

…candidate SNPs within miRNA binding sites of these genes can alter miRNAs binding and consequently, mRNA gene regulation.


2) Whole Transcriptome Analyses Reveal Differential mRNA and microRNA Expression Profiles in Primary Human Dermal Fibroblasts Infected with Clinical or Vaccine Strains of Varicella Zoster Virus (Republic of Korea) 10/10/19

This study identified genes and miRNAs that may be essential in VZV pathogenesis.

Differences in the clinical strains compared to the vaccine strains attest to the fact that reassembly of viruses in vaccines causes pathology via the same molecular mechanisms that link fixation of RNA-mediated amino acid substitutions to prevention of pathology via RNA interference.

The facts about the reassembly of viruses in vaccines continue to be ignored.

See: Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles 11/1/19

…we investigated the clinical consequences of morbillivirus infection and demonstrated a depletion of vaccine-acquired immunity to influenza virus, leading to a compromised immune recall response and increased disease severity after secondary influenza virus challenge. Our results show that MeV infection causes changes in naïve and memory B lymphocyte diversity that persist after the resolution of clinical disease and thus contribute to compromised immunity to previous infections or vaccinations. This work highlights the importance of MeV vaccination not only for the control of measles but also for the maintenance of herd immunity to other pathogens, which can be compromised after MeV infection.

The changes in immune system memory are oxygen experience-dependent. Viruses steal the energy that biophysically constrains amino acid substitutions in hosts and the viruses use it to adapt to the host before the host can adapt.

See: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution 1/22/13

Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.

The major antigenic changes in other viruses have not been considered in the most recent reports that promote vaccinations and the virus-driven pathology they cause via reassembly.

See:  A New Discovery Upends What We Know About Viruses 3/14/19

Instead, the vax pushers keep pushing.

See also:

Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens 11/1/19

The reduction in humoral immune memory after measles infection generates potential vulnerability to future infections, underscoring the need for widespread vaccination.

Reported as:  Measles erases immune ‘memory’ for other diseases 10/31/19

See for comparison: Exosomal microRNA in autoimmunity  10/29/19

The energy-dependent miRNA-mediated pheromone-controlled assembly of the miRNA-RNA-peptide nanocomplex links miRNAs in mammalian milk exosomes to miRNAs in semen exosomes that protect organized genomes from the virus-driven degradation of messenger RNA.

See: From Fertilization to Adult Sexual Behavior (1996)

See also: Let food be thy medicine and medicine be thy food? The obsessive worship of “medicinal foods”  6/1/15

For a critical review of how decades of pseudoscientific nonsense was incorporated into the practice of Western medicine, see:

Vax pushers have failed to consider the role that the energy-dependent assembly of the microRNA-RNA-peptide nanocomplex plays in autophagy, which biophysically constrains viral latency. Injecting people with viruses disrupts that natural protection of organized genomes because the viruses steal the energy that cell types need for differentiation.



Author: James Kohl

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