MicroRNA-mediated healthy longevity (3)

Unraveling the Molecular Signature of Extracellular Vesicles From Endometrial-Derived Mesenchymal Stem Cells: Potential Modulatory Effects and Therapeutic Applications 12/20/19

Photosynthesis has been linked to:

The biological mechanisms underlying endMSCs function have been associated to their immunomodulatory capacity (Nikoo et al., 2012), which is mediated—at least in part—by indoleamine 2,3-dioxygenase-1, cyclooxygenase-2, IL-10, and IL-27 (Peron et al., 2012; Nikoo et al., 2014).

This article is part of the Research Topic MSC Signaling in Regenerative Medicine View all 8 Articles

See for comparison: MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination 11/5/13

They linked photosynthesis to their finding that:

…miR-200/ZEB forms a tristable circuit that acts as a ternary switch, driven by miR-34/SNAIL, that is a monostable module that acts as a noise-buffering integrator of internal and external signals.

Any or all microRNAs may buffer the integration of internal and external signals. That fact strikes terror into the hearts of biologically uninformed theorists. It means that photosynthesis activates the energy-dependent endogenous substrates of all cell types, which refutes all claims that the cell types of different species evolved.

Light-activated carbon fixation is the only obvious link to sympatric speciation across kingdoms and that fact was made perfectly clear on January 2, 2020.

See: The predictive power of the microbiome exceeds that of genome-wide association studies in the discrimination of complex human disease

If you look at the number of people who “retweeted” this admission (in a preprint) of what some may believe is a “new scientific truth” you may also begin to realize why pseudoscientists and other theorists are scared. They know that more serious scientists will comment on claims from Genome-Wide Association Studies, which biologically uninformed theorists consistently failed to link from food energy-dependent pheromone-controlled RNA interference to healthy longevity via Microbiome-Association Studies and the effective treatment or prevention of all virus-driven pathology.

One year after publication of The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging, which was reported as Targeting an RNA-binding protein to fight aging 1/10/19, intelligent serious scientists must ask two questions:

1) Who will be next to link God’s Creation of energy as information to the ATP-dependent creation of  the RNA-binding protein PUM2, which biophysically constrains viral latency and all pathology during aging.

2) Who will be the last to stop pretending that God’s Creation of sunlight and water has not been linked from oxygen-dependent ecological adaptations to healthy longevity via the physiology of reproduction and biophysically constrained viral latency?

See these three patents for food energy-dependent pheromone-controlled biophysically constrained viral latency:

Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis

RNA-Guided Human Genome Engineering 

Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest 12/25/18

See also their: Proof of concept

Has it really been more than a year since the patented cure for all cancers was issued and reported?


For a historical perspective see: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Happy Healthy New Year! For an example of what intelligent people (at Genius Games et al., )  recently did with the facts from 1964 about ATP-dependent RNA synthesis, see these links from microbiome association studies to healthy longevity for ages 10-14+
Virus Expansion
Genotype (2020):

Theorists lost their ability to prevent another generation from learning how to link God’s Creation of energy-as-information to biophysically constrained viral latency and healthy longevity via the physiology of reproduction, and Mendel’s works with peas, and what is now known about pea proteins.

After three generations of Ph.Ds from 1944 until 2020, all intelligent people know that pea proteins do not create themselves. See: Energy as information and constrained endogenous RNA interference (2/15/17)

Author: James Kohl

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