Abstract excerpt: “Resurrected proteins reveal that ancestral uricases have steadily decreased in activity since the last common ancestor of mammals gave rise to descendent primate lineages. We were also able to determine the 3D distribution of amino acid replacements as they accumulated during evolutionary history…”
My comment: This is an important refutation of mutation-driven evolution. The refutation is based on models of climate change and diet change that lead to nutrient-dependent pheromone-controlled de novo gene creation, chromosomal rearrangements and ecological adaptations. The ecological adaptations occur with loss of genes and stabilization of the genome, which is manifested in the morphological and behavioral phenotypes of different species from microbes to man. See for example: Dobzhansky (1973) link opens PDF: Nothing in Biology Makes Any Sense Except in the Light of Evolution. This refutation of mutation-driven evolution shows us that nothing about evolution makes sense except in the light of biologically-based ecological adaptations.
Media report: Medical research February 18, 2014