Light and life at base pair resolution (4)

MicroRNA from Small Oligunucletoides to Giant Players of Biological Processes and Diseases (2019)

My summary:

Bioinformatic data should only be used to set up experiments with results that support of refute what has been learned from in vitro studies via cell culture linked to experiments in animal models, which must be linked to results in humans. The relevance of miRNAs has been established in that context and examination of microRNA-mediated cause and effect is essential to the development of natural sciences, biology, and medicine. The facts about the energy-dependent creation of microRNAs will linked to all future advances in the prevention and therapy of chronic degenerative diseases via what is known to all serious scientists about naturally occurring RNA-mediated DNA repair.

For instance, Yoav Gilad’s group published this preprint, on December 4, 2018. A comparison of gene expression and DNA methylation patterns across tissues and species

The censors at the bioRxiv preprint server typically block my comments to Disqus, such as this one, which is “pending”

Their claim is obtuse “…gene expression divergence in conserved tissue-specific genes can be explained by corresponding inter-species methylation changes more often.”

For comparison see: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events

Others need only dispense with silly claims about the emergence of energy and mutation-driven evolution. By linking the creation of energy to gene expression via multiple interspecies reassortment events, serious scientists arrived at the conclusion that during times of nutrient stress or social stress, viruses adapt faster than hosts adapt to viruses.

That is why vaccines are effective only in the short-term. In the long-term stress-linked viral replication links the energy that is required to prevent the degradation of RNA to mutations, which are linked to all pathology. Food energy-dependent fixation of RNA-mediated amino acid substitutions is linked to healthy longevity.

The 2011 medical thriller “Contagion” integrated fact about “Multiple Interspecies Re-assortment Events” into the plot.

The facts clearly link the creation of the sun’s anti-entropic virucidal energy to the creation of ATP and the creation of RNA and the creation of the sense of smell in bacteria. Start with McEwen et al., (1964): Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See for comparison: The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands

Our computational analysis also reveals a new mechanism of histamine binding, which underlines an important role of Tyr250 residue. The present work is, to our best knowledge, the first study of nuclear quantum effects on ligand receptor binding.

Quantum effects on ligand receptor binding are ATP dependent and RNA mediated.

The more recent article was reported as: Using the ‘deuterium switch’ to understand how receptors work

John Hewitt, a biologically uninformed theorist, placed the role of the Tyr250 residue into the context Hugo de Vries definition of mutation (a sudden energy jump – no ATP, no RNA.)

Type V receptors tunnel electrons across a gap that corresponds to an energy jump by binding a molecule that possesses one or more vibrations at the correct energy. Type T have the same circuit topology, but without an energy jump. The receptor is turned on when a molecule binds to it and includes a feature, such as a positive charge, that lowers the barrier to electron tunneling. Finally, type r receptors only have the output half of the circuit where the ligand brings in the electron, and then undergoes an oxidation step when bound.

Was the oxidation step a type of “oxidative phosphorylation?” If so, where did the energy come from for the oxidation step?

The fact that Evolutionists Cannot Account for the Origin of the Sense of Smell attests to the lack of explanatory power when theorists and so-called science journalists, like John Hewitt, assume that energy jumps somehow link mutations to evolution.

From What is life? (1944)

1. But about forty years ago the Dutchman de Vries discovered that in the offspring even of thoroughly pure-bred stocks, a very small number of individuals, say two or three in tens of thousands, turn up with small but ‘jump-like’ changes, the expression ‘jump-like’ not meaning that the change is so very considerable, but that there is a discontinuity inasmuch as there are no intermediate forms between the unchanged and the few changed. De Vries called that a mutation.
2. We know definitely, today, that Darwin was mistaken in regarding the small, continuous, accidental variations, that are bound to occur even in the most homogeneous population, as the material on which natural selection works. For it has been proved that they are not inherited.

For comparison, Wen Zhou’s group placed the creation of the sense of smell into the context of the energy-dependent space-time continuum and linked everything known to scientific creationists about light-activated microRNA biogenesis to our visual perception of mass and energy.

See: Olfaction Warps Visual Time Perception link opens pdf

Our findings, along with others (Johnston et al. 2006; Xuan et al. 2007; Wang and Jiang 2012; Mayo and Sommer 2013), suggest a parallel in the perception of time––subjective time is “warped” by the neural energy involved in representing multisensory inputs at subsecond scales.