New imaging techniques have linked The Art of Building Small, from molecular switches to motors (2016 video) and cryo electron microscopy (cryo-EM) from light-activated microRNA biogenesis to energy-dependent changes in angstroms and ecosystems in my model of biophysically constrained viral latency.
See: Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches 12/18/18 link opens pdf
MicroRNA (miRNA)-regulated in vitro-transcribed mRNAs, called miRNA switches, have been used to control the expression of exogenous mRNA in a cell-selective manner.
From the pdf:
Post-transcriptional modifications of RNA are frequent, conserved across species, and observed in different RNA classes. These modifications distinguish endogenous RNA molecules from invading viral or microbial RNA molecules.
The ability to distinguish between viral and microbial RNA links the viruses in microbes to all diseases and energy-dependent biophysical constraints on viral replication in microbes from fixation of amino acid substitutions to healthy longevity via the differentiation of cell types in all living genera.
See for example: MicroRNA signature changes during induction of neural stem cells from human mesenchymal stem cells 1/18/19
…miRNAs that are involved in the differentiation of neural stem cells (NSC) from human mesenchymal stem cells (MSC) were completely profiled and identified to elucidate the significant miRNAs responsible for NSC differentiation.
These types of ncRNAs are involved in different biological processes including brain development, maturation, differentiation, neuronal cell specification, neurogenesis, and neurotransmission. Increasing data has demonstrated that miRNAs and lncRNAs have strong correlations with the development of NDs, particularly gene expression.
See for review: What is life when it is not protected from virus driven entropy (2016 video)
See for comparison (with my emphasis): Engineered Adaptability: Biological Networks Feature Finest Engineering Principles 12/28/18
Knowing the basics of logic-based regulatory control is necessary for understanding ICR’s adaptation model called continuous environmental tracking (CET).
ICR’s adaptation model of is my model of light-activated ecological adaptation, which they place into the context of continuous environmental tracking (CET). Here’s an example of how the CET series has tracked the scientific progress I have reported without mention of microRNAs or the virus-driven degradation of messenger RNA that causes all diseases.
So far, there are no identifiable needless or foolish biological regulatory systems.
So far, there is no automagical optimization of genomes in response to the environment. Even Darwin knew that “conditions of life” came before natural selection. All biological regulatory systems are energy-dependent and microRNA-mediated. Those conditions are equivalent to Darwin’s “conditions of life.”
Medical laboratory scientists learn that the amount of available energy is the basis for quality control in all departments where testing is performed. For an example of biological systems complexity, I was able to determine that the blood gas analyzer was not calibrated for the elevation above sea level in the last 3 labs where I worked. (They were at 4500 ft, 5100 ft, and 1800 ft above sea level, respectively.) The errors in reporting of excessively high pO2 were due to calibration errors that also linked elevated levels of external controls to differences in the potential of hydrogen (pH).
The pH balance is linked to energy-dependent changes in pCO2 and in pO2, which are referred to as blood gases in the context of blood gas analysis. Light activated carbon fixation is the link from cyanobacteria to plants in the context of hydrogen and oxygen.
That fact is a threat to young earth creationists who have plagiarized my life’s work and left out the facts about microRNAs and viruses.
The virus-driven degradation of messenger RNA occurs with a slight change in the pH of cell types, and the change links the replication of viruses to all diseases. Continuous Environmental Tracking (CET) cannot be ICR’s model of adaptation until they admit that the tracking links the creation of the sun’s anti-entropic virudical energy to healthy longevity via the physiology of reproduction in all living genera.
Simply put, ICR has tracked the scientific progress made during the past 2-3 decades by serious scientists but the progress linked viruses to all pathology and that was ignored by most Creationists.
The progress is tractable from my first peer-reviewed publication with co-authors in 1996, From Fertilization to Adult Sexual Behavior, to my last, in 2018: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems
This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experiencedependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity. Species-specific pheromones link quorum-sensing in microbes from chemical ecology to the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection for codon optimality links nutritional epigenetics to the behaviors that enable ecological adaptations. All biodiversity is an ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. Simply put, olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.
If the ICR series on “Engineered Adaptability” placed the virus-driven degradation of messenger RNA into the proper context, no theorist could provide an acceptable argument against the experimental evidence. Had I not met a young earth creationist who discussed his beliefs as he performed 30+ skin cancer surgeries, I might otherwise have still had questions – despite 40 years experience with testing in the medical laboratory.
In any case, ICR parrots the fact that most diagnosticians have used to link the creation of electrons and photons from the proton motive force to changes in the potential of hydrogen (pH) that make life and death differences to all cell types in all individuals of all species on Earth. But, ICR and most theorists do not start with the creation of energy.
That is why ICR and neo-Darwinian theorists failed to link light-activated affective neuroscience to my group’s claims about the epigenetic effects of food odors and pheromones on microRNA-mediated biophysically constrained viral latency.
See: Selected Principles of Pankseppian Affective Neuroscience Jan 17, 2019
Jaak Panksepp’s career spanned 50 years (Davis and Montag, 2018). Throughout, he worked to provide compelling evidence that animals experienced their emotional arousals: at least all mammals, probably all vertebrates, and with the likelihood that even some invertebrates such as crayfish (separated from humans by perhaps 600 million years) exhibited conditioned preferences to distinct visual environments…
Panksepp’s group published Comparative approaches in evolutionary psychology: molecular neuroscience meets the mind (2002) and won the same award that my group won for publishing Human pheromones: integrating neuroendocrinology and ethology (2001)
The effect of sensory input on hormones is essential to any explanation of mammalian behavior, including aspects of physical attraction. The chemical signals we send have direct and developmental effects on hormone levels in other people. Since we don t know either if, or how, visual cues might have direct and developmental effects on hormone levels in other people, the biological basis for the development of visually perceived human physical attraction is currently somewhat questionable. In contrast, the biological basis for the development of physical attraction based on chemical signals is well detailed.
What is known about microRNAs and nucleotide resolution, links the virus-driven degradation of messenger RNA to all pathology. That fact eliminates all claims about the evolution of invertebrates to humans. Organisms that fail to find enough food to ecologically adapt die. Individuals dies and species become extinct when too many individuals die.
But see: Light-activated continuous environmental tracking (2) for a newly reported old alternative: Mutation-driven evolution.