Light-activated chemogenetic kinetics (1)

Hydrophobic catalysis and a potential biological role of DNA unstacking induced by environment effects 8/14/19

…hydrophobic interactions may have catalytic roles also in other biological contexts, such as in polymerases.

Reported as: DNA is held together by hydrophobic forces 9/23/19

Researchers at Chalmers University of Technology, Sweden, disprove the prevailing theory of how DNA binds itself.

The prevailing theory was ridiculous. It included no global biogeochemical constraints on the virus-driven degradation of messenger RNA, which all serious scientists linked from mutations to all pathology.

See for comparison: From hydrogen atom transfer in DNA base pairs to ecosystems 7/31/16

For ridicule of all pseudoscientists who have failed to link the light-activated energy-dependent assembly of the microRNA-RNA-peptide nanocomplex, also known as the polycomb repressive complex, to hydrophobicity and the functional structure of supercoiled DNA, see this from 12/10/14:

 

For more information on how supercoiled DNA is linked from protection of the virus-driven degradation of messenger RNA to healthy longevity, see:

MicroRNA Networks Modulate Oxidative Stress in Cancer 9/11/19

 …miRNAs are involved in ROS production or ROS-mediated function.

Investigating the interactions between ROS and miRNAs

…is expected to aid in the development of effective treatment/prevention strategies for cancer [and all virus-driven pathology.]

See also:

MicroRNA miR-1002 Enhances NMNAT-Mediated Stress Response by Modulating Alternative Splicing 8/30/19

These results outline a new process for microRNAs in regulating alternative splicing and modulating stress resistance.

The results link light-activated microRNA biogenesis to viral latency across kingdoms via the physiology of reproduction and fixation of RNA-mediated amino acid substitutions in organized genomes via the modulation of energy-depenedent alternative splicing.

See also: MicroRNA miR-1002 Enhances NMNAT-Mediated Stress Response by Modulating Alternative Splicing 8/30/19

I reiterate:

These results [DO NOT] outline a new process for microRNAs in regulating alternative splicing and modulating stress resistance.

See: From Fertilization to Adult Sexual Behavior (1996)

“Small intranuclear proteins” [light-activated endogenous substrates] generate “alternative splicing techniques of pre-mRNA” [aka microRNAs] “and, by this mechanism, contribute to sexual differentiation in at least two species…”

No new mechanisms of energy-dependent biophysically constrained RNA-mediated cell type differentiation have been discovered since 1964.

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

 The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See also:

Author: James Kohl

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