Kohl and Francoeur at 25 (8)

Epigenetic Regulations in Neuropsychiatric Disorders (4/4/19)

This article is part of the Research Topic: Genetics and Epigenetics of Psychiatric Diseases

For a historical perspective on their claims about epigenetic effects on the brain and behavior, see: Human Endogenous Retroviral Envelope Protein Syncytin-1 and Inflammatory Abnormalities in Neuropsychological Diseases (9/7/18)

Nutrient stress and social stress have since again been linked to the reactivation of human endogenous retroviruses (HERVs) and all pathology, not just the pathology linked to neuropsychiatric disorders.

The links from HERVs to neuropeptides and psychiatric disorders were detailed in the context of:

1)Gonadotropin releasing hormone and human sexual behavior (1991) in Neuropeptides and Psychiatric Disorders

2)Pheromones (2010) from Stress Science: Neuroendocrinology

3) Olfaction Warps Visual Time Perception  (2018) and

4) Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)

My mentors, the late Robert L. Moss and Bruce S. McEwen, are not mentioned in any of the citations from Epigenetic Regulations in Neuropsychiatric Disorders (4/4/19). It’s as if an entire generation of biologically uninformed theorists prevented the dissemination of accurate information about biophysically constrained viral latency until (and after) the mammalian milk exosome was linked from the transgenerational epigenetic inheritance of healthy longevity to all biodiversity via the physiology of reproduction in bacteria and plants.

Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

Microbe-Host Communication by Small RNAs in Extracellular Vesicles: Vehicles for Transkingdom RNA Transportation

Quantifying the contribution of dietary protein to whole body protein kinetics: examination of the intrinsically-labeled proteins method

I could elaborate on the following issues, if required to make the point that neo-Darwinian theorists left out the fact that food energy is required to meet Darwin’s “conditions of life.”

But these topics have already been discussed on this blog site.

Living things move. Movement requires energy.

Browning motion vs flagellar movements

Weekend resurrection of the bacterial flagellum

Creation of enzymes and kinetics

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Author: James Kohl

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