Is schizophrenia due to a gene of large effect?

Single gene might explain dramatic differences among people with schizophrenia

“…dramatic differences seen among patients with schizophrenia may be explained by a single gene that regulates a group of other schizophrenia risk genes.”

My model details how the epigenetic tweaking of immense gene networks by nutrients, which is controlled by the metabolism of nutrients to pheromones, causes the development of physical diseases and mental disorders. This article focuses on a particular version of the microRNA-137 gene (or MIR137) instead of microRNA /messenger RNA homeostasis.

Many people seem unable to grasp the concept of microRNA /messenger RNA homeostasis. Is the problem due to what’s taught about the role of random mutations in runaway selection for mutations? Was anyone taught anything about the epigenetic effects of nutrient stress and social stress on the microRNA / messenger RNA balance, which is essential to the concept of biologically based adaptive evolution?

Did anyone ever ask how random mutations result in anything that’s adaptive in the context of the requirements for ecological, social, neurogenic, and socio-cognitive niche construction? Is there evidence that sex differences are somehow involved in a random mutation results in expression of a particular version of the microRNA-137 gene at different times in males compared to females? If so, we could compare evidence that people think supports random mutations theory to the biological facts of rapid regulatory evolution via the de novo emergence of other microRNAs that are essential for the development of the brain and behavior in the human lineage.

Author: James Kohl

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