Information Wars started by medical professionals (5)

Usage of microRNAs (miRNAs) which are small noncoding RNAs is one of the molecular research lines for the diagnosis and treatment of cancers. miRNAs have an important role in post-transcriptional regulation of the gene expression and are involved in cellular activities such as growth, differentiation, cell death and cancer development… the expression level of PBX2 oncogene, a validated target gene of hsa-let-7c-5p, is evaluated by RT-qPCR to show the effectivity of this approach on erythroleukemia cancer cells. Our results can be used in translational medicine for future investigation in acute erythroleukemia and to approach treatment based on miRNA mimic therapy.

miRNA mimic therapy is exemplified as First RNAi Therapy Approved by FDA

After 16 years, tireless perseverance through near-death moments, billions of dollars in investment, we’ve finally succeeded in advancing RNAi therapeutics as a whole new class of innovative medicines,” Alnylam CEO John Maraganore says in an email to Xconomy.

How can the practice of medicine, which will be based on miRNA mimic therapy in Iran and in the United States of America, be compared to the practice of medicine in Egypt via the claims of Mohammad Saad Zaghloul Salem, who appears to have learned nothing about quantized energy-dependent RNA-mediated cell type differentiation during the past two decades?

Medical practice in Egypt appears to be at least a decade behind research in the United States

See: microRNA egypt

See also: microRNA iran

See also: microRNA USA 

See also: FDA approves first-of-its kind targeted RNA-based therapy to treat a rare disease

Since its discovery in 1998, scientists have used RNA interference as a tool to investigate gene function and its involvement in health and disease. Researchers at the National Institutes of Health, for example, have used robotic technologies to introduce siRNAs into human cells to individually turn off nearly 22,000 genes.

This new class of drugs, called siRNAs, work by silencing a portion of RNA involved in causing the disease. More specifically, Onpattro encases the siRNA into a lipid nanoparticle to deliver the drug directly into the liver, in an infusion treatment, to alter or halt the production of disease-causing proteins.

Natural selection for quantized energy-dependent codon optimality links RNA interference to healthy longevity in all living genera.

See: Codon usage of highly expressed genes affects proteome-wide translation efficiency (co-author, George M. Church)

For comparison:  A Sweeping Role for MicroRNAs in Neuronal Disease, Vascular Disorders, and as Prognostic Indicators (USA)

What about Israel? Thanks for asking. See: microRNA Israel

See also: Interactions between short and long noncoding RNAs  (Israel)

…lncRNA expression can be repressed by small RNAs, and lncRNAs can affect small RNA activity and abundance through competition for binding or by triggering small RNA degradation. Here, I review the known types of interactions between small and long RNAs, discuss their outcomes, and bring representative examples from studies in mammals.

5/28/18 You are blocked from following @IgorUlitsky and viewing @IgorUlitsky’s Tweets.

See also: Principles of Transgenerational Small RNA Inheritance in Caenorhabditis elegans (Israel)

On 7/27/18, the first author,  Oded Rechavi blocked me on Twitter after reporting  A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
If you are not blocked, see: https://twitter.com/OdedRechavi/status/1022685610274902016

… these results suggest it is possible to predict phase-separation properties based on amino acid sequences.

This is the message that I get: You are blocked from following @OdedRechavi and viewing @OdedRechavi‘s Tweets.

Oded Rechavi and Igor Ulitsky may be among the few researchers in Israel who have failed to link light activated microRNA biogenesis to biophysically constrained viral latency and all biodiversity via the pheromone-controlled physiology of reproduction and predictable phase-separation properties based on amino acid sequences. The predictable properties link fixation of amino acid substitutions to the differentiation of all cell types of all individuals of all species.

See for comparison: Eibi Nevo: Evolution, Let’s Get It Right, It’s the “Basis of Everything” (August 14, 2015)

Nevo is professor emeritus at the University of Haifa, Israel. His research includes environmental stress and evolution, speciation, and model organisms.

…you see dramatic differences in the biodiversity between the savannoid African and forested European slopes. . . . This represents a cradle of sympatric speciation, i.e., the origination of new biological species within freely inbreeding populations…

Young earth creationist / scientists put the claims about sympatric speciation into the perspective of perfect creation perturbed by viruses in: Viral Genome Junk Is Bunk 

Then, they changed everything with the claims in “Celebrate Your Inner Virus.”

The fact that God Created anti-entropic virucidal light, which links light-activated microRNA biogenesis to biophysically constrained viral latency via the physiology of reproduction in Biblical Genesis, went missing from the perspective of young earth creationists in the USA and elsewhere, but not from the perspective of young earth creationists in South Korea.

What about South Korea? microRNA “republic of korea”

See also: A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

…plants alter microRNA (miRNA) biogenesis in response to light transition.

Researchers like Oded Rechavi and Igor Ulitsky may think they can bury the facts about light-activated microRNA biogenesis by blocking me from seeing their “Tweets.”  If I could see what they were doing, I would comment and expose their nonsense.

For example, on July 27, 2018, I wrote: Scientific creationists have linked the creation of the sun’s anti-entropic virucidal energy to microRNA biogenesis and healthy longevity. Theistic evolutionists twist the facts about microRNA biogenesis and tout mutaton-driven evolution. But see A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

… these results suggest it is possible to predict phase-separation properties based on amino acid sequences.

I reiterate, that’s what scared Oded Rechavi. He failed to link what nematodes eat to the differences between C. elegans and P. pacificus, a predatory nematode with teeth.

Serious scientists know that the late Eshel Ben-Jacob established the facts about light-activated endogenous substrates and biophysically constrained cell type differentiation in nematodes and in all other organisms.

See: Bacterial self-organization: co-enhancement of complexification and adaptability in a dynamic environment (2003) and in: Learning from Bacteria about Natural Information Processing (2009)

See also: Seeking the foundations of cognition in bacteria: From Schrödinger’s negative entropy to latent information (2006) and MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination (2016)