Levulan Kerastick and Blu-U link light-activated microRNA biogenesis in plants to an effective treatment for the virus-driven degradation of messenger RNA in skin cells via the physiology of pheromone-controlled reproduction (quorum-sensing) in soil bacteria, gut bacteria, and skin bacteria.
The problem for theorists is that the available light-activated clinical therapy, which was unknown to Ben Feringa, refutes their theories about mutations and evolution by placing natural selection for energy-dependent codon optimality first in the context of Darwin’s “conditions of life.” Neo-Darwinists subsequently bastardized Darwin’s claims by placing natural selection before “conditions of life.”
That fact was clarified in The Grand Unified Theory of Classical Physics, which linked the creation of subatomic particles to the elimination of all theories from Big Bang cosmology to neo-Darwinian pseudsocientific nonsense and Ben Feringa includes a slide representation with this quote:
Disabled were walking again, the blind were seeing again, and the death rose from the grave. 2013 was the year in which prophesy from the bible became reality. — De Correspondent dec 2013
Analysis of the peptide–receptor interfaces reveals that the charged N-terminal residues of the peptides are mainly selected through electrostatic interactions, whereas the C-terminal segments are recognized via both conformations and interactions. The detailed molecular picture obtained by this approach opens a new gateway for exploring the complex conformational and chemical space of peptides and peptide analogs for designing GPCR subtype-selective biochemical tools and drugs.
Reported as: Lock and key become flexible
G-protein-coupled receptors (GPCRs) are critically involved in signal transduction. Structural views of several GPCRs have recently been obtained, but the structural principles determining subtype selectivity are still mostly elusive. Now, a combined solid-state NMR and molecular-modeling approach reveals how bradykinin GPCRs distinguish between closely related peptide ligands.
Nobel Laureate, Ben Feringa mentions the importance of amino acid substitutions to the functional structure of all cell types. The substitution of achiral glycine in position 6 of the gonadotropin releasing hormone (GnRH) decapeptide links the difference in two amino acids to differences in peptides. That places everything known about cell type differentiation back into the context of light-activated pheromone-constrained viral latency via quorum sensing in bacteria.