See the discussion section of A radical new holistic view of health based on cooperation and disease based on competition
Mention of a Hermetic principle: “Whatever is below is similar to that which is above” led me to information about the Hermetic Principle of Cause and Effect, which seems pertinent to include in the context of health based on cooperation and disease based on competition.
My comment: Is the Hermetic Principle of Cause and Effect more commonly known as “x” acts on “y” and causes “z”? If so, in the context of healthy adaptive evolution, “x” is cooperation in nutrient acquisition that causes beneficial effects in populations where “y” is the altered thermodynamics of intercellular signaling that leads to intranuclear interactions and nutrient-dependent stochastic de novo creation of olfactory receptor genes.
Randomness is eliminated because the metabolism of nutrients to species-specific pheromones that control reproduction leads to “z” via competition for well-nourished mates in species that sexually reproduce. A well-nourished mate is one who has the enhanced nutrient-dependent ability to thermoregulate the thermodynamics of its organism-level existence. Organism-level thermoregulation is a function of olfactory and immune system integration (i.e., self vs non-self recognition) via epigenetic effects of the sensory environment on conserved molecular mechanisms in species from microbes to man. In yeasts, for example, at the advent of sexual reproduction, we find that it is nutrient-dependent and pheromone-controlled.
Conserved molecular mechanisms enable nutrient-dependent pheromone-controlled alternative splicings via fixation of new alleles in all species. Healthy nutrient-dependent amino acid substitutions, which are required for adaptive evolution, result from epigenetic effects of food “odors” on experience-dependent receptor-mediated behavior. See for review: Nutrient-dependent/pheromone-controlled adaptive evolution: a model.
Mutations perturb health by altering healthy receptor function and randomly disabling nutrient-dependent control of stochastic gene expression by pheromones that signal reproductive fitness and control reproduction, thus controlling the population-wide spread of mutations. That’s why mutations are not not beneficial, not fixed, and are associated with diseases and disorders, but not healthy “adaptive” evolution.
It would be great to see cause and effect incorporated into medical models of health-based cooperation and mutation-driven disease-based competition for nutrients. But first, given my history of publications that have explained the conserved molecular mechanisms, we may need to dispense with the ridiculous theory of mutation-driven evolution. It serves only to confuse people about cause and effect via misrepresentations of what mutations may do, which they cannot do because they do not enable fixation. See, for review: An experimental test on the probability of extinction of new genetic variants.