God, Escher, Mitchell (1)

Summary: Light-activated microRNA biogenesis is the pathway to the functional significance of all peptides. If you learn the difference between a mutation and an amino acid substitution in a peptide, you will never successfully become a biologically uninformed pseudoscientist.

This blog post does not include a philosophical perspective. For that nonsense see:

Gödel, Escher, Bach: An Eternal Golden Braid, also known as GEB, is a 1979 book by Douglas Hofstadter. By exploring common themes in the lives and works of logician Kurt Gödel, artist M. C. Escher, and composer Johann Sebastian Bach, the book expounds concepts fundamental to mathematics, symmetry, and intelligence. Through illustration and analysis, the book discusses how self-reference and formal rules allow systems to acquire meaning despite being made of “meaningless” elements. It also discusses what it means to communicate, how knowledge can be represented and stored, the methods and limitations of symbolic representation, and even the fundamental notion of “meaning” itself.

Now, Jill Escher tries but fails miserably take the make meaning from GEB and link it to at least three things she knows nothing about: Physics, Chemistry, and Molecular Epigenetics.

See: Meet the originator of epigenetic inheritance, Charles Darwin 7/24/18 by Jill Escher

Atheists and other biologically uniformed theorists failed to realize that God is the originator of epigenetic inheritance. Until now, Jill Escher exemplified that failure.

Like most people, she still cannot grasp the subtle differences in Physics and Biology that require a connection to molecular epigenetics from the most obvious source of anti-entropic virucidal energy: SUNLIGHT

See for comparison: On the Difference between Physics and Biology: Logical Branching and Biomolecules

…energy or entropy considerations will not by themselves produce the desired logical structures and operations that enable the function and purpose characteristic of life [52] to emerge.

That is why Jill Escher should not consider Charles Darwin to be the originator of epigenetic inheritance. Darwin failed to link the physiology of reproduction to biophysical constraints on species diversity in the context of God’s physics of infinity. Darwin did not know enought about God’s Creation, and yet Jill Escher wants to elevate Darwin’s widely acclaimed status for comparison to what scientific creationists know about God.

See: The physics of infinity

My summary: Nothing automagically emerges. Every aspect of God’s Creation is quantized energy-dependent and the energy is conserved in the context of the space-time continuum via links from the creation of subatomic particles to light energy dependent microRNA biogenesis and microRNA-mediated cell biology.

See: Olfaction Warps Visual Time Perception

My summary: They linked the sense of smell in bacteria from the physiology of pheromone-controlled reproduction to our visual perception of energy and mass in context of the space-time continuum.

I playfully put the facts about the space-time continuum into the context of “Kohl’s Laws of Biology.” I knew that other serious scientists would understand what I did and why I did it.

See: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems

Concluding paragraphs:

The plausibility and ecological validity of Kohl’s Laws in the context of Darwin’s ‘conditions of life’ can be compared to theories about biologically-based cause and effect in the context of species diversity. In mammals, for example, the explanatory power of a model of ecological variation and biophysically constrained nutrient-dependent pheromone-controlled ecological adaptations became clear with companion papers published in 2013. See for review [26].

The companion papers [159,160] told a new short story of ecological adaptations. In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China. Apparently, the effect of the epiallele was adaptive and it was manifested in the context of an effect on sweat, skin, hair, and teeth. In another mammal, such as the mouse, the effect on sweat, skin, hair, and teeth is probably due to a nutrient-dependent epigenetic effect on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones.

The pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated. The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [159,160]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.

Jill Escher now admits to recently learning about Darwin’s “conditions of life.”  Kevin Mitchell’s attack on my life’s work prompted her responses.

None of the people involved in discussions are commenting on the accurate representations made by all serious scientists since the time of Schrodinger (1944) What is Life? They won’t discuss the facts that I have detailed in my history of published works or in presentations like this:  What is life when it is not protected from virus driven entropy 3/30/16 (video)

The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

In this blog post, George FR Ellis (winner of the 2004 Templeton Prize) is God’s representative. He watches Jill Escher, Kevin Mitchell, and others ignore everything known to all serious scientists. In their twitter feeds, others are helping Kevin Mitchell and/or Jill Escher to create the perfect storm of what Richard Feynman referred to in his comment on the human idiocy displayed by theoretical physicists.

Clearly, the present is the key to the past, and theorists are living in the Darwinian or neo-Darwinian past.

The “Wiring of the Brain” is quantized energy-dependent and the energy is biophysically constrained in food.  Light-activated endogenous substrates are the only obvious link from the epigenetic landscape and food to the physical landscape of supercoiled DNA, which exists only in the context of the food energy-dependent physiology of reproduction.

After all is said and done by biologically uninformed theorists, you may want to return to the comment about my model that George FR Ellis made in 2014. See: Understanding and accounting for relational context is critical for social neuroscience

I wrote:

“New data on how genetic predispositions are epigenetically linked to phenotypically distinct neuroanatomy and behaviors is provided in the honeybee model. Across-species comparisons from insects to vertebrates clearly show that the epigenetic influence of food odors and pheromones continues throughout the life of organisms that collectively survive whereas individuals do not. These comparisons also attest to the relative salience of sensory input from the rearing environment. For example, when viewed from the consistency of animal models and conditioned behaviors, food odors are obviously more important to food selection than is our visual perception of food. Animal models affirm that food odor makes food either appealing or unappealing. Animal models reaffirm that it is the pheromones of other animals that makes them either appealing or unappealing.

Socioaffective neuroscience and psychology may progress more quickly by keeping these apparent facts in mind: Olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans (Keller et al., 2007; Kohl, 2007; Villarreal, 2009; Vosshall, Wong, & Axel, 2000).”

— Kohl, JV (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors Socioaffective Neuroscience & Psychology 2012 (17 Apr 2014 at 03:07am)

George F R Ellis

This is absolutely correct and forms part of the larger concept that top-down causation is a key factor not just in the way the brain works but in broader contexts in biology and even physics. This is explored here: https://rsfs.royalsocietypublishing.org/content/2/1.toc 25 Apr 2014 at 07:49am

See the Table of Contents from the Top-down causation conference organized by George F. R. Ellis, Denis Noble and Timothy O’Connor. Introduction  Top-down causation: an integrating theme within and across the sciences? (February 6, 2012)

My review of epigenetic influences on behavior was published on March 15, 2012. Until recently, attempts to place top-down causation into the context of God’s Creation of the sun’s anti-entropic virucidal energy were blocked by the process of peer-review.

You can imagine the horror of finding that someone like Kevin Mitchell reviewed your submission. But it’s not just a problem with people like him. My failure to place ecological adaptations back into the context of evolution ensured that some publication attempts would be futile.

The best book editor I ever knew also ensured that, against my will, my co-author Robert T. Francoeur included mention of some nonsense about mutations in The scent of eros: mysteries of odor in human sexuality. I protested, but Dr. Francoeur made sure the book got published.

He knew that our future success as individuals and the future of all species would not be determined by the use of a meaningless word like mutation compared to the facts about food energy-dependent pheromone-controlled ecological adaptations.

For comparison, and for another perspective on Kohl’s Laws of Biology / Darwin’s “conditions of life,” see: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition

Ask a pseudoscientist “Where do codons come from?” and learn what the creation of life includes. See for example:

The small peptide world in long noncoding RNAs 6/29/18

In this review, we discuss… coding potential and the functional significance of the peptides….

A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation 7/18/18

… plants alter microRNA (miRNA) biogenesis in response to light transition.

Light-activated microRNA biogenesis is the pathway to the functional significance of all peptides. If you learn the difference between a mutation and an amino acid substitution in a peptide, you will never successfully become a biologically uninformed pseudoscientist.

Mutation: Any change in the DNA sequence of a cell.

Peptide: A compound consisting of two or more amino acids linked in a chain.

Author: James Kohl

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