Gang rape among members of the ICGC/TCGA (1)
Caveat. Rape can also mean to plunder or strip something or someone of resources, such as funding required to make scientific progress after abandoning ridiculous theories.
Moving forward: It’s been 8 years since I published this review of food energy-dependent biophysically constrained viral latency and species-specific pheromone-controlled behaviors.
See: Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors 3/15/12
As the psychological influence of food odors and social orders is examined in detail, the socioaffective nature of olfactory cues on the biologically based development of sexual preferences across all species that sexually reproduce becomes clearer.
Who still accepts the claims of Keith R. Brunt et al., about the automagical self-renewal of stem cells from Stem cells and regenerative medicine — future perspectives. 3/8/12
The existence of stem cell self-renewal was postulated 4 decades before the proof was established in 1961 by studying somatic stem cells of the hematopoietic system….we conclude with the cautionary fact that we still do not fully understand many of the diseases we hope to treat. Stem cell therapy does offer new promise for therapy, but it cannot succeed without a thorough understanding of our expectations, which is achievable only through extensive basic science.
Despite billions of dollars in funding, basic science seems to be stuck in the past. Why hasn’t proper nutrition been linked to the prevention of virus-driven diseases via the physiology of reproduction. Is the problem due to failed pattern recognition among atheists and biologically uninformed theorists?
See: Patterns of somatic structural variation in human cancer genomes 3/5/20
Reported as: Pan-cancer analysis of whole genomes
This heterogeneity arises from the stochastic nature of Darwinian evolution.
See for comparison: MicroRNAs organize intrinsic variation into stem cell states 3/5/20
…the results presented here suggest that naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.
The claim that microRNAs organize intrinsic variation in stem cell states linked to coherently organized biology is not consistent with the claim that embryonic stem cells self-organize. The claim also is not consistent with Darwin’s claims about “conditions of life.” Only if his conditions were not food energy-dependent and controlled by the physiology of reproduction could they be linked to the stochastic nature of neo-Darwinian evolution.
See for comparison: MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20
The claim that light-activated microRNA biogenesis biophysically constrains viral latency across kingdoms has been supported at every level of examination in more than 99,000 indexed published works on PubMed that mention microRNA.
But see: Massive genome study unlocks secrets of how cancers form 2/6/20
The results were published Thursday in nearly two dozen papers in Nature and other Nature Research journals and represent the largest and most comprehensive study of whole cancer genomes ever.
What secrets? The virus-driven degradation of mRNA links mutations to all diseases. Energy-dependent miRNA biogenesis prevents all virus-driven pathology. See: Virus-mediated archaeal hecatomb in the deep seafloor (2016) and Eukaryotic plankton diversity in the sunlit ocean (2015)
The only secrets revealed in the papers in Nature and other Nature Research journals attest to the fact that neo-Darwinian theorists and Big Bang cosmologists have touted examples of human idiocy since the 1960’s.
See for instance: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
Without God’s Creation of sunlight and water, theorists cannot get from ATP-dependent RNA synthesis to biophysically constrained viral latency and all biodiversity on Earth.
They are forced to report nonsense in the context of the fossil record and dating methodology that attempts to support claims that are not based on God’s Creation of the energy in Uranium ores.
See: Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits 6/1/17
Presciently reported in 2005 and again on 7/18/14 as: Biologists discover electric bacteria that eat pure electrons rather than sugar, redefining the tenacity of life (2014)
See for comparison: A younger “earliest human migration” to Southeast Asia
The fossiliferous Sangiran dome in Central Java contains the oldest human remains in Southeast Asia and is thus considered to be one of the most important sites in human paleoanthropology. Researchers have discovered more than 100 hominid remains from at least three different early to middle Pleistocene hominid species (1). Although numerous dating studies have been conducted at this site, the accepted date of earliest hominin migration is controversial. On page 210 of this issue, Matsu’ura et al. (2) describe their combined use of uranium/lead (U/Pb) dating (crystallization age) and fission-track dating (volcano eruption age) on zircons from three key strata in the hominid-bearing layers of Sangiran.
The fossil record nonsense might make sense to those who do not understand the fact that Darwin’s “conditions of life” were food energy-dependent and that pheromones help to control viral latency in species from microbes to humans via the energy balance linked from fixation of amino acid substitutions to cell type differentiation and sympatric speciation.
See: A sugary input to leucine sensing 1/10/20
Mammalian cell growth is tightly linked to adequate supplies of growth factors and nutrients, including glucose and amino acids. The mechanistic target of rapamycin complex 1 (mTORC1) functions as a coincidence detector that supports anabolic metabolism when convergent growth factor– and nutrient-derived signals trigger mTORC1 kinase activation. Conversely, nutrient starvation suppresses mTORC1 activity and triggers a shift to catabolic pathways, such as autophagy, to support cell survival under austere conditions. An elaborate signaling apparatus has evolved to harmonize mTORC1 kinase activation and protein synthesis with supplies of leucine and other amino acids (1).
See also: Role of microRNA-122 in microcystin-leucine arginine-induced dysregulation of hepatic iron homeostasis in mice 3/14/20
MicroRNA-122 link the light-activated assembly of a cyclic heptapeptide hepatotoxin produced by cyanobacteria to expression in the liver of mice.
These results suggest that miR-122 agomir can prevent the accumulation of hepatic iron induced by MC-LR, which may be related to the regulation of hepcidin by BMP/SMAD and IL-6/STAT signaling pathways.
The across-kingdoms and across-species links to energy dependent pheromone-controlled sympatric speciation can also be view int he context of:
Glycemia regulation: from feedback loops to organizational closure 1/21/20 and the research topic Multilevel Organization and Functional Integration in Organisms that started with The Dynamical Emergence of Biology From Physics: Branching Causation via Biomolecules 1/25/19
Remember, nothing emerges from nothing and quantum coherence has been linked from light-activated carbon fixation in cyanobacteria and the physiology of reproduction to coherently organized biology via the anti-entropic energy-dependent Creation of biomolecules.
See also: The landscape of viral associations in human cancers 2/5/20
Viruses were detected in 382 genome and 68 transcriptome datasets. We found a high prevalence of known tumor-associated viruses such as Epstein–Barr virus (EBV), hepatitis B virus (HBV) and human papilloma virus (HPV; for example, HPV16 or HPV18). The study revealed significant exclusivity of HPV and driver mutations in head-and-neck cancer and the association of HPV with APOBEC mutational signatures, which suggests that impaired antiviral defense is a driving force in cervical, bladder and head-and-neck carcinoma.
That suggests quantum coherence has once again been linked from coherently organized biology to the microRNA-mediated prevention or effective treatment of all virus-driven pathology via biophysically constrained RNA interference across kingdoms.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.