Gang rape among members of the ICGC/TCGA (1)

Caveat. Rape can also mean to plunder or strip something or someone of resources, such as funding required to make scientific progress after abandoning ridiculous theories.

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG), known as the Pan-Cancer Project, is an international collaboration to identify common patterns of mutation in more than 2,600 whole cancer genomes from the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA).

Most of the members pitted themselves against the US government by reporting ridiculous claims in the context of neo-Darwinian theories and/or Big Bang cosmology. They probably thought they were safe from anything except more ridicule, but President Trump had already established the facts about how their corruption led to social media suppression of facts.

The prosecution of Charles M. Lieber helps to assure all serious scientists that any form of media suppression of facts will no longer be tolerated.

…Americans have seen their accounts suspended, banned, or fraudulently reported for unclear “violations” of user policies. …Trump asked Americans to share their stories of suspected political bias… and received thousands of responses—thank you…

Charles M. Lieber’s forthcoming infamy can be viewed in the context of this claim from Nanowired Bioelectric Interfaces 8/14/19

Biological systems have evolved biochemical, electrical, mechanical, and genetic networks to perform essential functions across various length and time scales.

Nearly all ICGC/TCGA members tried to validate claims about the evolution of biological systems in the context of nearly two dozen articles published in Nature and Nature-family journals on 2/5/20. Most seemed to ignore the virus-driven pathology of the new coronavirus from Wuhan all other virus-driven pathology across kingdoms.

See for exception: The landscape of viral associations in human cancers reported as: First comprehensive survey of virus DNA found within cancer cells 2/5/20

The researchers have explored mechanistic explanations for associations showing for example that viral integration may drive high telomerase expression which is tumourogenic and emphasised the potential importance of viral integration to the immune response.

Most of the other group members took Lieber’s ridiculous claims about the evolution of biological systems and placed them back into the context of Darwin’s “conditions of life,” which he repeatedly linked from ecological variation to ecological adaptations via what is now known about the food energy-dependent immune response. “Conditions of life” are food energy-dependent and constrained by the physiology of reproduction. Organisms that do not find enough nutritious foods do not become members of species. They die from starvation, which means they fail to produce enough offspring to maintain population growth.

See: The Origin of Species

IV. Natural Selection; or the Survival of the Fittest Difficulties of the Theory

IF under changing conditions of life…

V. Laws of Variation: Effects of the Increased Use and Disuse of Parts, as Controlled by Natural Selection

…variability is generally related to the conditions of life to which each species has been exposed during several successive generations.

VI. Difficulties of the Theory: Difficulties of the Theory of Descent with Modification

…allied species are descended from a common parent; and during the process of modification, each has become adapted to the conditions of life of its own region…

Darwin’s claims and Mendel’s claims have since been linked to a game for ages 14+ that teaches students how genotypes are Created.

See: Genotype: A Mendelian Genetics Game

…built upon Gregor Mendel’s work with genetics and pea plants.

For comparison, see the games played by theorists who refused to acknowledge that fact that the virus-driven degradation of messenger RNA has been linked from mutations to all pathology and the fact that RNA interference has been linked to all cures.

See: Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy 

RNAi has targeted exogenous genes in models of viral infection…

See for comparison:  The evolutionary history of 2,658 cancers

Cancer develops through a process of somatic evolution… these results determine the evolutionary trajectories of cancer, and highlight opportunities for early cancer detection.

Reported as: Signs of cancer that occur years before diagnosis could lead to earlier cancer detection 2/6/20

“We have learned that cancer is the endpoint of a lifelong evolutionary process that drives our cells. This process is fuelled by mutations in the cells’ genomes,” says Moritz Gerstung…

In another paper, the lifelong evolutionary process was linked to “…an event called chromothripsis, where a DNA strand breaks in many places at once and the pieces are rearranged incorrectly.”

See: Pan-cancer analysis of whole genomes

Excerpt:

This heterogeneity arises from the stochastic nature of Darwinian evolution. There are three preconditions for Darwinian evolution: characteristics must vary within a population; this variation must be heritable from parent to offspring; and there must be competition for survival within the population. In the context of somatic cells, heritable variation arises from mutations acquired stochastically throughout life, notwithstanding additional contributions from germline and epigenetic variation. A subset of these mutations alter the cellular phenotype, and a small subset of those variants confer an advantage on clones during the competition to escape the tight physiological controls wired into somatic cells. Mutations that provide a selective advantage to the clone are termed driver mutations, as opposed to selectively neutral passenger mutations.

Conclusion:

Extending the story begun by TCGA, ICGC and other cancer genomics projects, the PCAWG has brought us closer to a comprehensive narrative of the causal biological changes that drive cancer phenotypes. We must now translate this knowledge into sustainable, meaningful clinical treatments.

Heterogeneity is energy-dependent and biophysically constrained via the light-activated assembly of the microRNA-RNA-peptide nanocomplex.

See: RNAi and RNA-based regulation of immune system function (2005)

See also: MicroRNAs regulate APOBEC gene expression (2017)

…we highlight how microRNAs interact with the APOBEC gene family and post-transcriptionally regulate APOBEC gene expression…

For review, see: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans.

and

Plant MicroRNAs in Cross-Kingdom Regulation of Gene Expression 8/10/18

…various reports revealed that miRNAs could be transmitted between species to mediate cross-kingdom regulation by integrating into a specific target gene-mediated regulatory pathway to exert relevant biological functions. Some scholars and researchers have observed this as an attractive hypothesis that may provide a foundation for novel approaches in the diagnosis, prognosis, and treatment of disease.

Links across kingdoms have also been placed into the context of  Vitamin C in Plants: Novel Concepts, New Perspectives, and Outstanding Issues 11/9/19

Future Directions: The role of microRNAs in the regulation of AO activity in relation to stress perception and signaling must be resolved. Similarly, the molecular characterization of ascorbate transporters and mechanistic links between photosynthetic and respiratory electron transport and ascorbate synthesis/homeostasis are a  prerequisite to understanding ascorbate homeostasis and function.

Neo-Darwinian theorists and other pseudoscientists failed to link God’s Creation of sunlight and water to oxygen-dependent ecological adaptations via oxidative phosphorylation, plant growth, what organisms eat,  the functional structure of supercoiled DNA, the physiology of reproduction, which biophysically constrains viral latency and homeostasis. Their epic failure has caused all pathology. For example, see the latest report on the new coronavirus pathology from Wuhan.

The coronavirus has killed at least 565 people, all but two of them in China. The other two deaths were in Singapore and Hong Kong. More than 28,000 people have been infected with the virus, the vast majority of them in China.

See also: Immune system development varies according to age, location, and anemia in African children 2/5/20

Reported as: Charting immune system development in sub-Saharan African children 2/5/20

…the immune system does not develop the same way in children born on different continents…

More than 1800 human hemoglobin variants link similarities in immune system development to the stability of EDAR V370A in populations from Asia to the New World.

In my model, increased vitamin C via the ingestion of sago palm-like leaves and increased vitamin D, both of which are sunlight dependent, stabilized the organized genomes of mice and humans via fixation of the EDAR V370A allele, which has been linked to human populations from the Old World to the New World in far less time than the populations could have evolved. There is no evidence for anything except that fact that all populations of all species must ecologically adapt to viruses, like the coronaviruses that threaten to cause our species extinction.

See also: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

 

Author: James Kohl

1 thought on “Gang rape among members of the ICGC/TCGA (1)

Leave a Reply

Your email address will not be published. Required fields are marked *