If you are not yet sure that your career as a theorist has ended, please note: Games for ages 10+ link the creation of Subatomic particles from the creation of ATP and the creation of RNA to Cytosis, which protects all organized genomes from the virus-driven degradation of messenger RNA via RNA interference (RNAi). Without the creation of RNA there is no RNAi and the synthesis of RNA is energy-dependent. Say goodbye first to the celebrity scientists. Then wave goodbye to the neo-Darwinists.
But first, see: McEwen et al., (1964) Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
See also: Epigenetics: The Ultimate Mystery of Inheritance (6/13/2011) by Richard C. Francis
The light-activated assembly of the microRNA-RNA-peptide nanocomplex and RNAi were linked to the cure for all pathology via the creation of the sense of smell/olfaction in everything published by serious scientists since the time Schrodinger published What is life? (1944).
Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)
See for comparison: What is life when it is not protected from virus driven entropy 3/30/16 (audio/visual aid)
The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.
For the most recent publication that links the creation of the sense of smell to RNAi, see also: The Gene CG6767 Affects Olfactory Behavior in Drosophila melanogaster
…targeted RNAi experiments revealed that the gene CG6767, a gene of previously unknown function but predicted to encode an enzyme responsible for the synthesis and metabolism of nucleic acids, affects olfactory behavioral responses to 2,3-butanedione. Specifically, RNAi mediated knockdown of CG6767 expression in different neuroanatomical populations of the olfactory system suggests that this gene functions in local interneurons of the antennal lobe. These results reveal a new role for CG6767 and its importance in olfactory behavior.
Their results reveal the fact that the energy-dependent creation of “…an enzyme responsible for the synthesis and metabolism of nucleic acids…” is required to link the microRNA-mediated physiology of reproduction to biophysically constrained viral latency and all biodiversity on Earth.
Nucleic acid metabolism is the process by which nucleic acids (DNA and RNA) are synthesized and degraded. Nucleic acids are polymers of nucleotides. Nucleotide synthesis is an anabolic mechanism generally involving the chemical reaction of phosphate, pentose sugar, and a nitrogenous base.
Potential impacts of microbial symbionts as drivers of host speciation have been discussed frequently…, but their broader evolutionary significance fostering speciation remains controversial…, and standard models of speciation commonly disregard such impacts….
Standard models of speciation do not link the creation of energy as information to the creation of enzymes and the creation of nucleic acids to biophysically constrained viral latency and all biodiversity via the physiology of reproduction:
See for comparison:
For alternative facts (aka ridiculous theories), see this announcement: The 2019 International Workshop on Statistical Genetic Methods for Human Complex Traits March 4th–March 8th, 2019
The next workshop will be held in Boulder, Colorado, March 4th–8th, 2019, with John Hewitt and Matt Keller as Local Hosts, and Benjamin Neale, Broad Institute and Massachusetts General Hospital, and David Evans, Diamantina Institute, University of Queensland, as co-Directors. This advanced course is intended for those who are already familiar with the statistical and genetic principles for studying human complex traits and have some familiarity with programming in R. The course will focus on statistical methods for analyzing genome-wide association studies (GWAS) and genome sequence data.
Simply put, the course will be useless to anyone who might otherwise attempt to make scientific progress based on experimental evidence of top-down causation, which starts with the creation of enzymes such as ATPase and facts that have been obfuscated by most of the research funded by the John Templeton Foundation, which now includes research on Intellectual Humility in Public Discourse
The lack of intellectual humility has caused the obfuscation of facts to come back to haunt all biologically uninformed theorists.
See: Genome Wide Association Studies of Behavior are Social Science (2011) and Social Science is… Pseudoscience
See also the articles that are included in the context of a Templeton Foundation funded project, which led to publication of a special issue of “Behavioral Genetics.”
- A Genetic Investigation of the Well-Being Spectrum The interrelations among well-being, neuroticism, and depression can be captured in a so-called well-being spectrum (3-phenotype well-being spectrum, 3-WBS).
- Sibling Similarity in Metabolic Syndrome: The Portuguese Sibling Study on Growth, Fitness, Lifestyle and Health This study aims to estimate sibling resemblance in metabolic syndrome (MS) markers, and to investigate the associations of biological and behavioral characteristics with MS.
- Using Variation in Heritability Estimates as a Test of G × E in Behavioral Research: A Brief Research Note Better characterization of the sources of phenotypic variation in human behavioural traits—stemming from genetic and environmental influences—will allow for more informed decisions….
- The Problem of Non-Shared Environment in Behavioral Genetics The role of non-shared environment (NSE) in the development of psychological traits is usually comparable with that of the genotype. However, no specific factors of NSE with significant impact on such traits have been discovered so far.
- Etiological Distinction Across Dimensions of Math Anxiety Analyses have suggested math anxiety is a multidimensional construct. However, previous behavioral genetic work examining math anxiety was unidimensional.
- A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms We aimed to detect Attention-deficit/hyperactivity (ADHD) risk-conferring genes in adults.
- Did I Inherit My Moral Compass? Examining Socialization and Evocative Mechanisms for Virtuous Character Development Virtuous character development in children is correlated with parenting behavior, but the role of genetic influences in this association has not been examined.
- Physical and Cultural Inheritance Enhance Agency, but What are the Origins of this Concern to Establish a Legacy? A Nationally-Representative Twin Study of Erikson’s Concept of Generativity Generativity—showing concern to establish and guide future generations—has been argued to be a biological adaptation central to cumulative culture and survival, but also, in turn, to be a cultural adaptation…
- Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies Offspring outcomes are a function of maternal genetics operating on the intrauterine and postnatal environment, offspring genetics and environmental factors.
- Genetically Informative Mediation Modeling Applied to Stressors and Personality-Disorder Traits in Etiology of Alcohol Use Disorder A statistical mediation model was developed within a twin design to investigate the etiology of alcohol use disorder (AUD).
- Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster Circadian rhythms influence physiological processes from sleep–wake cycles to body temperature and are controlled by highly conserved cycling molecules. Although the mechanistic basis of the circadian clock has been known for decades, the extent to which circadian rhythms vary in nature and the underlying genetic basis for that variation is not well understood.
- SES-of-Origin and BMI in Youth: Comparing Germany and Minnesota We suggest that one source of the present obesity epidemic is social change that amplifies expression of genes both constraining SES attainment and facilitating weight gain.
- I Smell a Mouse: Indirect Genetic Effects on Voluntary Wheel-Running Distance, Duration and Speed Indirect genetic effects (IGEs; the heritable influence of one organism on a conspecific) can affect the evolutionary dynamics of complex traits, including behavior.
- A Fast Method for Estimating Statistical Power of Multivariate GWAS in Real Case Scenarios: Examples from the Field of Imaging Genetics In GWAS of imaging phenotypes (e.g., by the ENIGMA and CHARGE consortia), the growing number of phenotypes considered presents a statistical challenge that other fields are not experiencing (e.g. psychiatry an…
- Type I Error Rates and Parameter Bias in Multivariate Behavioral Genetic Models For many multivariate twin models, the numerical Type I error rates are lower than theoretically expected rates using a likelihood ratio test (LRT), which implies that the significance threshold for statistica…
- The Nature of the Shared Environment While a standard part of twin modeling, the magnitude of shared environment (c2) is rarely examined by comparing estimates obtained using other methods.
The magnitude of the shared environment was placed into the context of how the creation of the sense of smell was linked from the pheromone-controlled physiology of reproduction in bacteria to our visual perception of energy and mass in the context of the space-time continuum.
See: Olfaction Warps Visual Time Perception 3/17/17 and:
Neo-Darwinian theorists who failed to link the creation of the sense of smell from the ability to find food to the pheromone-controlled physiology of reproduction in species from microbes to humans are now preparing to run and hide.
See for comparison: Evolutionists Cannot Account for the Origin of the Sense of Smell