Summary: John Hewitt links de Vries definition of mutation (i.e., sudden energy jumps) to all biodiversity. I claim that food energy is required to biophysically constrain the virus-driven degradati0n of messenger RNA. Only if, in theory, food energy emerges from the void as did the energy from the “Big Bang,” can a “deuterium switch” automagically be linked to the understanding of how receptors work. If energy is required to create the receptors, the energy can be linked from the light-powered bacterial ion pump to the creation of GPCRs.
John Hewitt claims that G protein-coupled receptors (GPCRs) are frequently considered to be a predominantly Eukaryotic innovation. Supposedly, “…bacteria generally go for more direct-acting receptors with efficient built-in ion channels…”
He uses rhodopsin as an example of ‘seven transmembrane domain’ family of proteins, which are called GPCRs for comparison to the ancient light-powered bacterial ion pump.
That suggests that from the beginning of evolution the light-powered bacterial ion pump started to become more like a GPCR.
In my model of biophysically constrained viral latency, light-activated microRNA biogenesis is required to link the light-powered bacterial ion pump to the creation of GPCRs and to morphology and behavior across the time-space continuum. The sense of smell in bacteria has been linked to our visual perception of energy and mass.
See: Olfaction Warps Visual Time Perception (2018)
As mammals produce Dicer-dependent viral siRNAs to target RNA viruses, our findings suggest a possible role for mammalian RLRs and interferon signaling in the biogenesis of viral siRNAs.
In my model, the link from the light-powered bacterial ion pump of bacteria to the immune system of nematodes and the GPCRs that appear to protect mammals from the virus-driven degradation of messenger RNA extends across the time-space continuum of nutrient-dependent pheromone-controlled biodiversity in species from yeasts to primates.
See for example our section on molecular epigenetics in From Fertilization to Adult Sexual Behavior (1996)
We discuss upstream and downstream genes that are likely also to play crucial roles in the context of top-down food energy-dependent causation that links multigene interrelationships to profound impacts upon morphological phenotypes and behaviors. We add this for shock value and because it’s true.
Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus (Runge and Zakian, 1996; Wu and Haber, 1995).
More than 20 years later, I see no indication that John Hewitt has learned anything about biophysical constraints on food energy-dependent RNA-mediated cell type differentiation. For comparison, in 2016 he made claims about Type V receptors, which supposedly tunnel electrons across a gap that corresponds to an energy jump in the context of vibrations at the correct energy for comparison to Type T receptors that share the same circuit topology but exhibit no energy jump.
When I questioned his use of de Vries definition of mutation (a sudden energy jump), John Hewitt blocked me from further comments on social media and failed to respond to my comments on Disqus.