Bioinformatic data, although fundamental, are only a prerequisite to set up experiments aimed at supporting or denying their robustness initially in vitro in cell culture, thereafter in experimental animal models, and finally in humans. This scenario provides evidence of the relevance of miRNAs for the development of natural sciences, biology, and medicine giving the fact that these small oligonucleotides has become today giant players of a great variety of biological processes. Furthermore, miRNAs modulation may provide in the next future new advances in the prevention and therapy of chronic degenerative diseases.
…in this paper, we collected and introduced miRNA databases and some webbased tools that have been developed by various research groups. We have categorized them into different classes including databases for viral miRNAs, and plant miRNAs, miRNAs in human beings, mice and other vertebrates, miRNAs related to human diseases, and target prediction, and miRNA expression. Also, we have presented relevant statistical information about these databases.
The difference between relevant and irrelevant statistical information is clear. I repurchased the domain quantumsouls.pro to extend what’s known about quantum physics to light-activated microRNA biogenesis and consciousness.
That will be a waste of time and money if no one responds to the information already available on this domain and on the Autophagy.pro domain. The links from proper nutrition to biophysically constrained viral latency and consciousness have been revisited each time the focus returns to a specific vitamin or other influence of diet on the molecular mechanisms of cell type differentiation.
See: Albert Imre Szent-Gyorgyi (1893-1986), a Hungarian-born biochemist, was the first to isolate vitamin C, and his research on biological oxidation provided the basis for Krebs’ citric acid cycle. His discoveries about the biochemical nature of muscular contraction revolutionized the field of muscle research. His later career was devoted to research in “submolecular” biology, applying quantum physics to biological processes.
Ecological Niche Construction is Biophysically Constrained by Nutrient Availability
Nutrient-dependent epigenetic effects on histone modifications and DNA methylation play an important role in stabilizing cell type identity and in orchestrating many developmental processes. For example, vitamin C appears to stimulate histone demethylases, which appear to alter the de novo creation of functional G protein-coupled genes such as olfactory receptor genes [15-19].
Researchers recently rediscovered a nutrient-dependent epigenetic variant that links vitamin C to what is probably a glucose and glucose dehydrogenase-dependent base pair change. The base pair change results in addition of a methyl group to a cytosine base, which takes on a hydroxyl group to form different 5-hydroxymethylcytosines (5hmCs). Different 5hmCs are associated with differences in cell types that have the same genetic backgrounds. Nutrient-dependent epigenetically-marked bases help to explain how hundreds of cell types in the human body and in the brain  are differentiated and how they maintain their glucose-dependent and other nutrient-dependent receptor-mediated identities .
For example, calcitriol is the active form of vitamin D. Its effects on the microRNA(miRNA)/messenger RNA (mRNA) balance appear to protect against virus-driven energy theft linked from perturbed protein folding to colorectal cancer.
The study confirms a previous study that also found an association between neonatal vitamin D deficiency and an increased risk of schizophrenia. The findings support the hypothesis that the risk of schizophrenia could be reduced with the treatment of vitamin D deficiency during the earliest stages of life.
For comparison to the clear link from Vitamin C and from Vitamin D to effects on the microRNA/messenger RNA balance and the light-activated creation of G protein-coupled receptors, such as olfactory receptor genes, see: The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands
Our computational analysis also reveals a new mechanism of histamine binding, which underlines an important role of Tyr250 residue. The present work is, to our best knowledge, the first study of nuclear quantum effects on ligand receptor binding.
This was reported by John Hewitt in the context of mutations and evolution.
…olfaction is probably the space where these deuterium switches and chiral switches most informatively converge to elucidate how receptors might operate.
Type V receptors tunnel electrons across a gap that corresponds to an energy jump by binding a molecule that possesses one or more vibrations at the correct energy. Type T have the same circuit topology, but without an energy jump. The receptor is turned on when a molecule binds to it and includes a feature, such as a positive charge, that lowers the barrier to electron tunneling. Finally, type r receptors only have the output half of the circuit where the ligand brings in the electron, and then undergoes an oxidation step when bound.
…while rhodopsin is a GPCR, the ancient light-powered bacterial ion pump is probably not.
John Hewitt failed to place everything known to serious scientists about biophysically constrained electron tunneling into the context of a light-powered bacterial ion pump. For comparison, serious scientists linked the creation of the sun’s anti-entropic virucidal energy to the creation of ATP and the creation of RNA in 1964.
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
Pseudoscientists and so-called science journalists, such as John Hewitt, who continue to report findings in the context of mutations and evolution appear to have not learned anything about cell biology and energy-dependent cell type differentiation during the past 5 decades or more.
…molecular assays have revealed important roles of TEs and viruses in host genome evolution and organization.
Organized genomes do not “evolve.” The virus-driven degradation of messenger RNA forces food energy-dependent ecological adaptations via biophysically constrained RNA interference in the context of the physiology of reproduction and Biblical Genesis. Indeed, we are what we eat.