Gross Chromosomal Aberrations are Early Alarms for Malignancy: A Re-Emphasis (2017)
Conclusion
Neoplastic transformations of normal cells can be detected by searching for “Rogue” cells (Cells with chromosome aberrations) at an early stage much before the malignant stage becomes clinically detectable. Close relatives and sibs of cancer patients should be chromosomally investigated and each metaphase must be examined to locate marker dot(s)which are positive indicators of the onset of chromosomal mutagenesis culminating in to malignancy.
It is obvious that regulatory mechanisms underpin the robust, precise and flexible regulation of important, fitness-related genes.
…deleterious activity to be almost completely suppressed by inclusion of amino acids or dipeptides, which may suggest a productive relationship between protein and RNA from the outset.
The so-called “tuning” is quantized energy-dependent and microRNA biogenesis links the metabolism of food to the physiology of food energy-dependent reproduction. Autophagy links the metabolism of food to biophysically constrained viral latency. Examples of fixed food energy-dependent pheromone-controlled feedback loops link fixation of RNA-mediated amino acid substitutions to the differentiatiation of all cell types in all individuals of all living genera. The quantized energy-dependent pheromone-controlled fixation of amino acid substitutions links the physiology of pheromone-controlled reproduction in bacteria to the pheromone-controlled wiring of the human brain.
See: System-wide Rewiring Underlies Behavioral Differences in Predatory and Bacterial-Feeding Nematodes and Successful Reorganization of Category-Selective Visual Cortex following Occipito-temporal Lobectomy in Childhood
See for comparison: Spatial Control of Neuronal Metabolism Through Glucose-Mediated Mitochondrial Transport
Regulation glucose distribution evolves via feedback loops
For comparison see: Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal
…environmentally dependent levels of arousal evolved the ability to control their own blood supply directly.
The claims about evolved glucose distribution; the evolved ability to control the blood supply; and the evolution of microRNA targeting defense genes exemplify the human idiocy that starts when pseudoscientists and other theorist fail to link the creation of the sun’s anti-entropic virucidal energy from microRNA biogenesis to RNA-mediated biophysically constrained viral latency.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.