Epigenetic Transgenerational Actions

Michael Skinner (video)

2014 Forum: Epigenetic Transgenerational Actions of Endocrine Disruptors on Reproduction and Disease

The conserved molecular mechanisms of exposure-induced disease. A data-driven presentation that argues against the misrepresentations of evolutionary biology.

See also:

The natural history of transfer RNA and its interactions with the ribosome

Molecular mechanisms for the inheritance of acquired characteristics – exosomes, microRNA shuttling, fear and stress: Lamarck resurrected?

A symbiotic liaison between the genetic and epigenetic code

Epigenetic control of mobile DNA as an interface between experience and genome change

An invited but rejected review article about chemical ecology and nutritional epigenetics that encompasses all, or nearly all, of the accurate representations of epigenetic transgenerational actions above is available here:

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.

Author: James Kohl

Leave a Reply

Your email address will not be published.