Epigenetic effects underlie sexual preferences IV

Article excerpt: “All of the steps in Figure 2 could also be influenced by sex-specific regulation of miRNA [microRNA] levels that are known to influence sexually dimorphism of mRNA [messenger RNA] concentrations in the brains of mice, and to be influenced by epigenetic control that is heritable across at least one generation (Morgan and Bale 2011).”  (Rice, Friberg, & Gavrilets, 2012, p. 349)

My comment: The difference between my model and the one offered by Rice et al., is that I include more information about the molecular mechanisms responsible for “…sex-specific regulation of miRNA levels that are known to influence sexually dimorphism of mRNA concentrations in the brains of mice” and in other species from microbes to man.

Main conclusion: (Kohl, 2012Human pheromones: epigenetic effects of odors and their affects on behavior

This model of systems biology (“biological embedding”) represents:

1)Nutrient chemical-dependent and social stress-induced intracellular changes in microRNA and messenger RNA homeostasis

2) Intermolecular changes in DNA

3) Experience-dependent stochastic variations in de novo gene expression for odor receptors

4) The required gene-cell-tissue-organ-organ system pathway that links sensory input directly to gene activation in GnRH neurosecretory cells of the mammalian brain

5) The required reciprocity that links gene expression to behavior that alters gene expression (i.e. from genes to behavior and back)

Comments

comments

Author: James Kohl

Leave a Reply

Your email address will not be published. Required fields are marked *