Epigenetic effects on so-called genetic endemism (3)

Ribosomes and cryo-EM: a duet

…cryo-EM structures have revealed unprecedented insights into the function of ribosomes from a wide range of biological sources and in numerous physiological contexts. These include the discovery of a new mechanism of polypeptide synthesis and the identification of the roles of ribosomes in functional supercomplexes.

For comparison see: Criticisms of the nutrient-dependent pheromone-controlled evolutionary model by an undergrad who wrote a thesis on abiogenesis.

James Kohl presents an unsupported challenge to modern evolutionary theory and misrepresentations of established scientific terms and others’ research. It was a mistake to let such a sloppy review through to be published. — Andrew Jones, BA

Editor’s note

The 2013 review article by James Vaughn Kohl published in Socioaffective Neuroscience & Psychology and criticized in the above Letter to the Editor was subjected to standard peer review and the revised version was accepted by me after it had been accepted by both reviewers.

See for comparison: Euglena gracilis is a species of single-celled alga that is able to feed by photosynthesis or phagocytosis. Its cell surface changes shape from a thin cell up to 100 µm long to a sphere of approximately 20 µm.

Could any intelligent person think that this exemplifies an link from abiogenesis to biophysically constrained cell type differentiation?

Who do you know who could understand this? RNA-Seq employing a novel rRNA depletion strategy reveals a rich repertoire of snoRNAs in Euglena gracilis including box C/D and Psi-guide RNAs targeting the modification of rRNA extremities

…target modification of the 3′ extremities of rRNAs utilizing predicted base-pairing interactions with internally transcribed spacers (ITS), providing insight into the timing of steps in rRNA maturation.

All base-pairing interactions are energy-dependent and biophysically constrained by changes in the endogenous substrates of all cell types.

There are 14 results from this search for internally transcribed spacers and 6761 results from this search for endogenous substrates.

Light-activated endogenous substrates link microRNA biogenesis to viral latency and all biodiversity in species from microbes to humans. Internally transcribed spacers are not known to be important to serious scientists because they do not link the creation of anything to anything else except pseudoscientific nonsense and more pseudoscientific nonsense.

That make the reason for the link from light-activated microRNA biogenesis to the patent for naturally occurring RNA-guided human genome engineering perfectly clear. Even George Church mentioned the light-activated fixation of carbon in cyanobacteria.

Church Speaks: A Conversation With George Church [2.14.18]

The cyanobacteria fix [carbon via] light as well or better than land plants. Under ideal circumstances, they can be maybe seven to ten times more productive per photon

Although no one knows when photons were created or where photons are stored as subatomic particles, he proceeded to link the biophotonic energy of sunlight to protection from viruses.

If all of the material that they fix didn’t turn back into carbon dioxide, we’d have solved the global warming problem in a year or two. The reality, however, is that almost as soon as they divide and make baby bacteria, phages break them open, spilling their guts, and they start turning into carbon dioxide. Then all the other things around them start chomping on the bits left over from the phages.

Phages are the viruses in bacteria that steal the sun’s biophotonic energy, which is how they link the Virus-mediated archaeal hecatomb in the deep seafloor to this claim in this patent application:

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

The addition of the NIH as co-owner of the patent shows that the theistic evolutionist and NIH director, Francis Collins may be collaborating and/or cooperating with George Church and others who want to deliver a “billion dollar baby” in therapy. Their billion dollar baby will allow them to make money from what would otherwise be placed into the context of claims about how a change in diet would reduce the chances that you and your loved ones might otherwise have of getting cancer or having a mental illness.

See: Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy

RNAi has targeted exogenous genes in models of viral infection (hepatitis B virus (HBV), influenza virus, Ebola virus) and in tumor xenografts. Initial, RNAi-dependent trials aimed at the delivering siRNA locally or on objects, such as vascular endothelial growth factor (VEGF), for the treatment of the wet age-related macular degeneration and the respiratory syncytial virus (RSV) for the treatment of RSV infections but lately the efficient delivery of VEGF-specific siRNA is done by a direct injection into the vitreal cavity to the eye [55]. RNAi therapeutics through the direct delivery of siRNA into the lungs can treat RSV infection [56].

All diseases are cause by viruses, not just the ones that are mentioned above. Pseudoscientists cannot place the difference between endogenous genes and exogenous genes into the context of epigenetic effects on so-called genetic endemism until after they link the virus-driven degradation of messenger RNA to mutations and all pathology. Until then, they will continue to link mutations to evolution as if the virus-driven theft of energy as information was beneficial in the context of abiogenesis and internally transcribed spacers or enhancer RNA or quantitative trait loci (QTL), or any other obfuscatory term they can use to blind the masses.

The masses may never realize they are being allowed to suffer unnecessarily and die prematurely due to corporate and personal greed.

Author: James Kohl

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