Epigenetic effects on so-called genetic endemism (1)

A reminder: The Brain-Microbiome Axis: Links Between Neurological Disease and Microbiota on September 26, 2018 is likely to be a game changer for evolutionary theorists who have failed to link the creation of sunlight to all biophysically constrained ecological adaptations.

Endemism is the ecological state of a species being unique to a defined geographic location, such as an island, nation, country or other defined zone, or habitat type; organisms that are indigenous to a place are not endemic to it if they are also found elsewhere.

Ecological states of all species are energy-dependent. The energy come from sunlight, which has been linked to biophysically constrained viral latency.  The link from viral latency to supercoiled DNA makes it clear to anyone age 10+ that the creation of Subatomic particles must be linked to Cytosis, which protects all organized genomes from negative supercoiling and genomic entropy.

See: Differential Functional Constraints Cause Strain-Level Endemism in Polynucleobacter Populations

Simply put, strain-level endemism is functionally constrained by RNA-mediated amino acid substitutions.

See: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems

The companion papers [159,160] told a new short story of ecological adaptations. In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China. Apparently, the effect of the epiallele was adaptive and it was manifested in the context of an effect on sweat, skin, hair, and teeth. In another mammal, such as the mouse, the effect on sweat, skin, hair, and teeth is probably due to a nutrient-dependent epigenetic effect on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones.

The pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated. The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [159,160]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.

159. Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, et al. (2013) Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell 152: 691-702.
160. Grossman SR, Andersen KG, Shlyakhter I, Tabrizi S, Winnicki S, et al. (2013) Identifying recent adaptations in large-scale genomic data. Cell 152: 703-713.

Others have since modeled recent human evolution and placed it into the context of recent ecological adaptations.

See: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

No experimental evidence of energy-dependent top-down causation linked to ecological adaptations has been linked to positive selection that might have occurred circa 20,000 y ago. For contrast, see: Past 5,000 years prolific for changes to human genome

North and East Asian and New World populations are not endemic (unique to a defined geographic location). If the populations of humans evolved elsewhere and migrated to different locations, serious scientists might have found evidence to support the ridiculous claims of pseudoscientists (e.g., theorists who believe in neo-Darwinian evolution).

Instead, all experimental evidence of energy-dependent top-down causation links changes from angstroms to ecosystems via energy-dependent ecological adaptations. An ångström or angstrom is a unit of length equal to one ten-billionth of a metre.

Watch Jarrad T. Hampton-Marcell explain the functional constraints on human populations without linking the creation of the sun’s anti-entropic virucidal energy from changes in angstroms to supercoiled DNA, which protects bacteria in the ocean and all other organisms in all ecosystems from the virus-driven degradation of messenger RNA.

Note: He fails to include the fact that all ecosystems contain viruses that cause constraint-breaking mutations in bacteria. The viruses are linked from the creation of archaea and L-forms to all pathology on Earth.

Simply put, viruses steal the energy that is required to link nutrients and metabolism from amino acid substitutions to healthy longevity and superhuman performance exemplified in Biblical Genesis and in the creation of man-made structures like pyramids, which have been found in diverse geographical locations. Mesoamerican pyramids are similar to Egyptian pyramids but the New World structures reportedly bear only a very weak architectural resemblance to Egyptian pyramids.

I am not an architect. I am a medical laboratory scientists who knows that the functional structure of supercoiled DNA is biophysically constrained by energy-dependent ecological adaptations.

See: Virus-mediated archaeal hecatomb in the deep seafloor

See also: Branched Chain Amino Acids: Beyond Nutrition Metabolism

Amino acids (AAs) are best known as the nutrient substrates for protein synthesis…”

Jarrad T. Hampton-Marcell fails to link the energy-dependent creation of amino acids to biophysically constrained viral latency. That epic failure can be placed into the context of claims from Sutherland’s group.

See: A Light-Releasable Potentially Prebiotic Nucleotide Activating Agent

…a selective phosphate activating agent, namely methyl isocyanide, could plausibly have been produced from simple prebiotic feedstocks. We show that methyl isocyanide drives the conversion of nucleoside monophosphates to phosphorimidazolides under potentially prebiotic conditions and in excellent yields for the first time. Importantly, this chemistry allows for repeated reactivation cycles, a property long sought in nonenzymatic oligomerization studies.

See for comparison: Protocells and RNA Self-Replication

If a sufficient diversity of RNAs could be copied with reasonable rate and fidelity, then Darwinian evolution would begin with RNAs that facilitated their own reproduction enjoying a selective advantage.

The first indication that light-activated biophysically constrained protein folding chemistry could be linked to healthy longevity appeared in Biblical Genesis, and it was linked to food choice and the physiology of reproduction.

Darwin linked his “conditions of life” to healthy longevity. Szostak’s group ignores Darwin’s “conditions of life” and reports that Darwinian evolution might begin with RNAs that facilitated their own reproduction.

Perhaps that is why two of Szostak’s papers have already been retracted.

Retraction: Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display (2008)
Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication (2017)

A reminder: The Brain-Microbiome Axis: Links Between Neurological Disease and Microbiota on September 26, 2018 is likely to be a game changer for evolutionary theorists who have failed to link the creation of sunlight to all biophysically constrained ecological adaptations.

Author: James Kohl

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