I linked natural selection for energy-dependent codon optimality from fixation of the EDAR V370A variant in mice to humans.
See this Q and A with a theorist who asks but refuses to accept the answers to the question.
Do Genes and Polymorphisms Explain the Differences between Eastern and Western Societies?
Kiaris fails to prove his ultimate point: that differences in genetic polymorphisms between individuals in different societies explain how and why the societies in question are so different.
jvkohl The point has been proved in species from microbes to humans. The polymorphisms are food energy-dependent and they are biophysically constrained by the pheromone-controlled physiology of reproduction in populations of mice and humans.
jvkohl Environmental selection… through breast milk
“The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations…”
…in concert with the mouse to human model of EDAR V370A alleles.
Race__Realist Selection doesn’t explain trait fixation. See Fodor’s argument.
jvkohl See my review of epigenetics: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” I linked natural selection for energy-dependent codon optimality from fixation of the EDAR V370A variant in mice to humans.
Race__Realist When two traits are coextensive, how does selection distinguish between the free-rider and the fitness-enhancing trait?
jvkohl Fitness is enhanced in the context of the quantized energy-dependent creation of microRNAs that protect organized genomes from the virus-driven degradation of messenger RNA, which all serious scientists have linked from mutations to pathology, not fitness.
Race__Realist How does that answer the question posed to you?
jvkohl I answered with facts about biophysically constrained protein folding chemistry. Are you denying the facts to promote a pseudoscientific agenda? If so, tell me more about your agenda. I’m disgusted by people who claim I have not answered their question.
Race__Realist How does NS distinguish between coextensive traits where one trait causes fitness and the other is just a correlate of a cause of fitness? My “agenda” is to show that NS cannot possibly be an explanatory mechanism because there are no laws for trait fixation and NS is mindless.
jvkohl You have a remarkably foolish agenda. See Kohl’s Laws of Biology (aka Darwin’s “conditions of life”) in this review of nutritional epigenetics. “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems”
Race__Realist Which one of those laws shows that NS is a mechanism for speciation/trait fixation?
jvkohl The ones that links Bazzini et al (2016) to biophysically constrained biodiversity via what organisms eat and viral latency in all living genera. Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition
jvkohl If you do not agree that Kohl’s Laws of Biology biophysically constrain viral latency and all biodiversity see what Philip C. Ball is reporting after he challenged me to a “pissing contest.”
There’s…a lot you can do when you’re sufficiently well informed
Race__Realist It’s a law of trait fixation?
jvkohl Support any claim that it is not with experimental evidence you will be ignored and/or ridiculed by all serious scientists.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.