Summary: What aspect of evolved hecatombic pathology cannot be compared to polycombic ecological adaptations in the context of Predictive modeling of miRNA-mediated predisposition to alcohol-related phenotypes
Non-coding RNAs (ncRNAs) are key regulators in anti-viral responses and play diverse roles in various aspects of infection, including virus replication, persistence, and pathogenesis. In addition to host ncRNAs that are influenced and/or utilized during infection, both DNA and RNA viruses produce regulatory ncRNAs. These molecules can act to modulate gene expression, such as microRNAs encoded by several DNA viruses, or control RNA stability or epigenetic processes, such as some viral long ncRNAs. Ongoing questions include how viral ncRNAs contribute to immune evasion, whether ncRNAs act as virulence factors, how viruses hijack host ncRNAs, and how both viral and host ncRNAs coordinate to benefit virus replication.
This Special Issue will group together works on the latest advances in non-coding RNA studies related to virus infections in humans and animal model systems.
For this Special Issue, we will consider manuscripts on the following topics:
ncRNAs, including miRNAs, as regulators of cell signaling and anti-viral responses
novel functions of viral or host ncRNAs in virus replication
ncRNAs in viral pathogenesis
pre-clinical and clinical studies investigating the roles of ncRNAs in viral diseases
After you read the articles about microRNAs in the special issue, you may wake up to a world in which all serious scientists know that the virus-driven degradation of messenger RNA causes all pathology.
See also: Energy as information and constrained endogenous RNA interference (video)
Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.
The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.
This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.
For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.
See for comparison: Targeted Base Editing Systems Are Available for Plants and can readily be linked from the epigenetic effects of sunlight on microRNA biogenesis to the prevention of all pathology in humans via the use of RNA-guided endonucleases for targeted genome editing.
…these results provide an in-depth analysis of miRNA dysregulation in glioblastoma and demonstrate the potential utility of these data in the design of miRNA-regulated therapies for the treatment of brain cancers.
A Harvard and MIT trained physicist claimed that researchers linked the creation of the cell death gene to all pathology in the early-to-mid-1990s.
I do not believe in conspiracy theories because I know how the ignorance of theorists prevents the dissemination of accurate information.
See also: Fusion oncogenes-genetic musical chairs
Anderson et al. show that ∼40% of EWSR1-FLI1 fusions and all EWSR1-ERG fusions arise via a complex rearrangement pattern called chromoplexy, which was first identified in prostate cancer (4).
For comparison, see this report on food energy-dependent pheromone-controlled chromosomal rearrangements that appear to prevent virus-driven pathology in white-throated sparrrow morphs.
PZ Myers and his idiot minions attacked me for accurately representing the role that chromosomal rearrangements play in estrogen receptor α polymorphism that is linked to receptor-mediated morphological and behavioral diversity in all mammals.
This claim prompted the attack:
Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction.
Estrogen receptor α polymorphism has been linked to sexual orientation in homosexual rams and humans.
I do not understand why more people do not complain about these displays of human idiocy by people like PZ Myers and Jay R. Feierman, who wrote:
I am absolutely certain that if you showed this statement to any professor of biology or genetics in any accredited university anywhere in the world that 100% of them would say that “Random mutations are the substrate upon which directional natural selection acts” is a correct and true statement.
See what happens when only one expert complains the misrepresentations of biologically uninformed science idiots:
Public health and alcoholism researcher Dr. Michael Siegel, of Boston University, last week called on the National Institutes of Health, of which NIAAA and NCI are a part, to retract and apologize for the language. He charged that the wording misled people into thinking that only drinking to the point of impairment posed a cancer risk.
…alcohol metabolism products have been associated with an increase in NADH levels, which lead to histone modifications and changes in gene expression that in turn influence cancer susceptibility.
Quantized energy-dependent changes in the microRNA-mediated creation of all cell types links ethanol ingestion to cancer via the virus-driven theft of energy in gut bacteria, which links mutations to all pathology via the Virus-mediated archaeal hecatomb in the deep seafloor
What aspect of evolved hecatombic pathology cannot be compared to polycombic ecological adaptations in the context of Predictive modeling of miRNA-mediated predisposition to alcohol-related phenotypes
The predictive modeling in the mouse suggests other critics will link microRNA biogenesis to the EDAR V370A variant that links the mouse model to humans.
The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection…