I reiterate: The link from the anti-entropic virucidal energy of sunlight to naturally occurring RNA interference (RNAi) in plants and animals has since been placed into the context of how natural selection for energy-dependent codon optimality links amino acid and synonymous codon effects to translation and protein degradation, which contribute to protein‐to‐mRNA (PTR) ratios.
We then asked whether our amino acid effects on PTR ratios captured the effects of amino acids on protein degradation.
Others have not asked whether the biophysically constrained RNA-mediated fixation of amino acid substitutions prevents the virus driven degradation of messenger RNA and protein degradation.
For example of a misrepresentation, see: Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies.
…the COMT Val158Met polymorphism fails to explain the differences in sensitivity to environment.
The differences in the environment cause the differences in sensitivity that have been linked from the COMT Val158Met polymorphism to healthy longevity or to virus-driven developmental outcomes linked to psychosis. Non-invasive testing for variant alleles is readily available for interpretation in the context of the National Microbiome Initiative and the Precision Medicine Initiative.