We didn’t know it was possible for cells to survive crisis; we didn’t know autophagy is involved with the cell death in crisis; we certainly didn’t know how autophagy prevents the accumulation of genetic damage.
They knew nothing of importance to any serious scientist who has linked natural selection for energy-dependent codon optimality from biophysically constrained RNA interference to the physiology of reproduction and healthy longevity in all living genera.
See also this example: A universal trend of amino acid gain and loss in protein evolution.
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
That suggests healthy longevity automagically evolved.
But wait, Eugene Koonin also claimed:
If healthy longevity evolved, the role of viruses was not considered. If viruses caused all diseases, that fact was not considered in the context of proteogenomics.
See for comparison: A deep proteome and transcriptome abundance atlas of 29 healthy human tissues 2/18/19
Only 238 of 9,848 amino acid variants found by exome sequencing could be confidently detected… showing that proteogenomics remains challenging, needs better computational methods and requires…”[common sense]