Energy-dependent enzyme catalysis

Please remember to take all the ridiculous theories and put them where the sun doesn’t shine!

This representation of the “theory” is from 2012. There is no more theory. A thoroughly detailed energy-dependent mechanism links subatomic particles from energy-dependent changes in angstroms to ecosystems in all living genera via what is know about biophysically constrained viral latency:

Reactions occur when reactant molecules contain enough “activation energy” to cross the potential energy barrier. The potential energy barrier typically is removed via the potential of hydrogen. The potential of hydrogen (pH), which is manifested in the context of “activation energy,” comes from the sun.

See: Schrödinger (1944) What is Life?

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)

Light-activated microRNA biogenesis has since been linked from the creation of enzymes and the physiology of reproduction to all biodiversity on Earth via the potential for hydrogen-atom transfer in DNA base pairs in solution. The transfer of energy to base pairs links RNA-mediated DNA repair to fixation of amino acid substitutions that differentiate all the cell types of all individuals of all species.

See: Structural diversity of supercoiled DNA and

See also: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)

I used the example of the EDAR V370A variant, which has since been linked from the mouse-to-human model of biodiversity to differences in human populations.

See: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

The claim about divergence that occurred ~20,000 years ago is a spurious claim. See for comparison: MicroRNAs: regulators of neuronal fate

…many microRNAs could also function locally, such as at the growth cone or at synapses modulating synaptic activity and neuronal connectivity.

For comparison, see the forthcoming claims in Kevin J. Mitchell’s Innate How the Wiring of Our Brains Shapes Who We Are

Innate also explores the genetic and neural underpinnings of disorders such as autism, schizophrenia, and epilepsy…

Michell and others like him have missed more than 120 years of scientific progress that clearly links epigenetically effected cell type differentiation from the virus-driven degradation of messenger RNA to all pathology.

A Case of Hystero-Epilepsy Simulating “Status Epilepticus.” (1897) and Epigenetic changes in status epilepticus (2018)

In 1974, I was trained in the US Air Force to link endogenous substrates from enzyme activation in test tubes to quantitative chemistry test results via spectophotometry (measurement of changes in light).  In the early 1980’s, I developed a model of energy-dependent cell type differentiation. In the early 1990’s, Bruce McEwen told me my mammalian model could not be validated until I learned how gene activation in hormone-secreting nerve cells of the hypothalamus occurred. The late Robert L. Moss told me about his forthcoming publications on gondadotropin releasing hormone (GnRH), and Bruce McEwen agreed that the feedback loops from activation to organization of effect of others hormones on behavioral affects was complete.

As indicated in the works published by all serious scientists since then, it continues to appear that “…chance favors the prepared mind,” — Louis Pasteur was correct. Sudden flashes of insight are the products of preparation that may take decades of collaborative efforts and discussions with experts in different disciplines. (McEwen: molecular biology; Moss: endocrinology)

Clearly, people like Kevin J. Mitchell are not prepared to accept any insight. In his twitter feed, he referred to me as a troll.  See for comparison: Mitchell’s Genetic entropy and the human intellect (2013) for comparison to Nutrient-dependent/pheromone-controlled adaptive evolution: a model (Kohl, 2013) and Mutation-Driven Evolution (Nei, 2013)

Mitchell pits his latest claims about how the constant vigilance of selection prevents the threats to the intellect of species, which is posed by new mutations (i.e., Nei’s anything that happens to a gene), against everything known to serious scientists about biophysically constrained viral latency. The facts about viral latency can be learned by ages 10+ via game-play of “Cytosis“(viral latency) and “Subatomic” (anti-entropic virucidal light activated microRNA biogenesis).

See also these responses to the pseudoscientific nonsense touted by Mitchell and Nei, and many others before and after 2013.

Our fragile intellect. Part I

New developments in genetics, anthropology, and neurobiology predict that a very large number of genes underlie our intellectual and emotional abilities, making these abilities genetically surprisingly fragile.

Our fragile intellect. Part II

Analysis of human mutation rates and the number of genes required for human intellectual and emotional fitness indicates that we are almost certainly losing these abilities. If so, how did we get them in the first place, and when did things begin to change?

and Rethinking our intellectual origins: response to Kalinka et al.

The citation to Fu, W. et al. (2013) Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature 493, 216–220 might be all you need in the context of MicroRNAs: regulators of neuronal fate (2013) to dispense with the pseudoscientific nonsense of theorists during the next 120 years of scientific progress.

See also: US Air Force Studying Impact of Exome Sequencing in Routine Care and What are whole exome sequencing and whole genome sequencing?

Please prepare yourself to review the pseudoscientific nonsense touted by Kevin J. Mitchell via a search for key words at:

Innate How the Wiring of Our Brains Shapes Who We Are

2 results for energy

2 results for entropy: both are citations to Mitchell (2013)

22 results for epilepsy

0 result for virus

See for comparison from (NIH): epilepsy virus 851 results and energy enzyme 87377 results energy enzyme catalysis 4576 results


Author: James Kohl

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