Rethinking Pre-Agricultural Humans
Analysis of a 7,000-year-old human genome suggests that Mesolithic people had relatively dark skin and had begun to evolve pathogen resistance characteristic of modern Europeans.
By Tracy Vence | January 28, 2014
Excerpt: “Also interesting was that the researchers found that the ancient human carried ancestral alleles in several skin pigmentation genes, leading them to conclude that he likely had dark skin and light eyes.”
My comment to “The Scientist”
Their table lists nutrient-dependent SNPs; amino acid substitutions; and function(s). In my model, these are also epigenetically-effected by the metabolism of nutrients to pheromones that control the physiology of reproduction in species from microbes to man.
“Olfactory-Based Fat Discrimination in Humans” links fat detection and nutrient uptake from the bottom-up via conserved molecular mechanisms.
Our sensitivity to human body odors links them from the top-down to the pheromone-controlled physiology of reproduction via the same signaling pathway found in yeasts (see our 1996 Hormones and Behavior review).
Therefore, this representation of changes in skin pigmentation and changes in eye color appears to exemplify nutrient-dependent pheromone-controlled ecological adaptations that have been consistently attributed to mutation-initiated natural selection.
If, as suggested, de novo mutations were involved, the biological plausibility and ecological validity of the theory of mutation-driven evolution could be compared to the likelihood that the changes in skin pigmentation and eye color during a relatively short time were due to nutrient-dependent de novo gene creation sans mutations.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.