Ecological adaptation vs neo-Darwinian nonsense (2)

Understanding quantum physics in the context of the light-activated assembly of the nucleic acid-microRNA-peptide nanocomplex (L-ANAMPNC or L-ANC, for short) is essential to the understanding how the cure for all diseases has been linked from quantum physics to quantum souls.

Some people with dementia seem to have lost their souls. For example, the death of Robin Williams was originally reported to be a suicide, before findings linked what some might have called a ‘lost soul’ to Lewy Body Disease. Thank God treatments are beginning to be developed based on what can be learned by ages 10+ by playing:

Subatomic: An Atom-Building Board Game

Game play links: Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism (2015) to: Cytosis: A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

The light energy as information-dependent fixation of RNA-mediated amino acid substitutions links the L-ANC from the creation of sunlight, the creation of ATP and the creation of nucleic acids to the effective treatment and/or to the effective treatment of all diseases.

For example, see: Nucleic Acid-Based Therapeutics for Parkinson’s Disease (2/12/19)

Alternative disease-modifying strategies focus on downregulating the expression of the alpha-synuclein gene using various techniques, including modified antisense oligonucleotides, short hairpin RNA, short interfering RNA, and microRNA. The latter approaches also have implications for dementia with Lewy bodies. Other PD genes can also be targeted using nucleic acids.

Treatments that start from the creation of nucleic acids link the creation of the sun’s anti-entropic virucidal energy to the light-activated simultaneous creation of the building blocks of life.

The treatment protocol can be linked to this claim: Researchers may have solved origin-of-life conundrum (3/16/15)

…researchers-may-have-solved-origin-life-conundrum the conditions that produce nucleic acid precursors also create the starting materials needed to make natural amino acids and lipids. That suggests a single set of [light activated] reactions could have given rise to most of life’s building blocks simultaneously.

See also: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Everyone who has since linked age-related diseases from food energy to thymic involution may be able to understand how the L-ANC

Metformin Treatment Suppresses Melanoma Cell Growth and Motility Through Modulation of microRNA Expression (2/11/19)

Metformin is an oral biguanide drug used for diabetes and has demonstrated positive effects on cancer prevention and treatment.

The positive effects can be linked to the energy source that fuels proper cell type differentiation until excessive sugar intake links the virus-driven theft of energy to all pathology in all living genera.

For a strike force-like example of how the virus-driven degradation of messenger RNA has been linked from the L-ANC to the deterioration of the cell wall in bacteria to archaea and L-forms (cells without walls),  see: Virus-mediated archaeal hecatomb in the deep seafloor (10/12/16)

For an equally striking example of human idiocy, see: A universal trend of amino acid gain and loss in protein evolution (2/10/2005)

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

For comparison, see: Feedback loops link odor and pheromone signaling with reproduction (11/18/2005)

L-ANC links the feedback loops from biophysically constrained viral latency to sympatric speciation via the physiology of pheromone-controlled reproduction in species from microbes to humans.  The facts about feedback loops and viral latency address Darwin’s “abominable mystery.” He did not know how the creation of light was linked to the appearance of flowering plants in the fossil record. And so, he and many others simply assumed that everything that automagically evolved after energy automagically emerged from nothing, took billions to millions of years to do it outside the context of God’ s Creation of sunlight.

Ribosomal DNA harbors an evolutionarily conserved clock of biological aging (2/14/19) from the Cold Springs Harbor Press journal of Genome Research.

Our observations identified an evolutionarily conserved marker of aging that is easily ascertained, grounded on nucleolar biology, and could serve as a universal marker to gauge individual age and response to interventions in humans as well as laboratory and wild organisms across a wide diversity of species.

For comparison, see: nucleolar biology  Items: 1 to 20 of 2273

The anti-viral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion  (2/4/19)

Our results indicate that the anti-viral protein viperin controls chondrogenic differentiation by influencing secretion of soluble proteins and identify a molecular route that may explain impaired chondrogenic differentiation of cells from individuals with CHH.

Reported as: Ribosomal DNA Can Predict an Animal’s Age

If you cannot link the food energy-dependent creation of anti-viral proteins from L-ANC to the prevention or to the effective treatment of all diseases, thank the researchers from Cold Springs Harbor Labs and others who claim that “Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.”

See for comparison: Ribosomal DNA and the nucleolus in the context of genome organization (1/17/19)

The nucleolus constitutes a prominent nuclear compartment, a membraneless organelle that was first documented in the 1830s. The fact that specific chromosomal regions were present in the nucleolus was recognized by Barbara McClintock in the 1930s, and these regions were termed nucleolar organizing regions, or NORs. The primary function of ribosomal DNA (rDNA) is to produce RNA components of ribosomes. Yet, ribosomal DNA also plays a pivotal role in nuclear organization by assembling the nucleolus.

The creation of sunlight is required to link the L-ANC to the creation of ATP and RNA. Remember L-ANC is short for light-activated assembly of the nucleic acid-microRNA-peptide nanocomplex, which is required for nuclear organization and genome organization via assembly of the nucleolus.

See also: The chromatin landscape of the ribosomal RNA genes in mouse and human (1/8/19)

Recent studies applying a novel Deconvolution Chromatin Immunoprecipitation (DChIP-Seq) technique in conjunction with conditional gene inactivation provide new insights into the structure of the active rRNA genes and question previous assumptions on the role of chromatin and histone modifications. We suggest an alternative model for the active rRNA gene chromatin and discuss how this structure is determined and maintained.

This is the model of energy-dependent biophysically constrained RNA-mediated structure and function that links fixation of the amino acid substitution, EDAR V370A from the mouse-to-human model of pheromone-controlled morphological and behavioral phentoypes to the prevention of all diseases.

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (4/18/18)

It links the works of Barbara McClintock to the works of Rosalind Franklin to what is known about how supercoiled DNA protects the organized genomes of all living genera from the virus-driven degradation of messenger RNA that links mutations to all diseases.

For comic relief from the pseudoscientific nonsense touted by biologically uninformed theorists and those who profit from unnecessary suffering and premature death, see:


Or, see the more technical representation of this group’s work: Structural diversity of supercoiled DNA (10/12/15)

Our results reveal that each topoisomer, negative or positive, adopts a unique and surprisingly wide distribution of three-dimensional conformations. Moreover, we uncover striking differences in how the topoisomers handle torsional stress. As negative supercoiling increases, bases are increasingly exposed. Beyond a sharp supercoiling threshold, we also detect exposed bases in positively supercoiled DNA. Molecular dynamics simulations independently confirm the conformational heterogeneity and provide atomistic insight into the flexibility of supercoiled DNA. Our integrated approach reveals the three-dimensional structures of DNA that are essential for its function.

See also: Small Nucleolar RNAs Tell a Different Tale (12/16/18)

During the past decade, it has become apparent that RNAs transcribed from noncoding regions of the genome play essential functions in various biological processes. This prompted researchers to gain an understanding of how noncoding RNA (ncRNA) biogenesis is controlled and whether (and how) this process resembles synthesis of messenger RNA (mRNA).

The synthesis of mRNA is biophysically constrained by the creation of virucidal light in the context of light-activated microRNA biogenesis and the L-ANC.

The ‘tale’ that’s being told is one in which continuous environmental tracking links the creation of sunlight to biophysically constrained viral latency and all biodiversity via the physiology of pheromone-controlled reproduction in species from bacteria to humans.  It is the Young Earth Creationist’s tale in the Engineered Adaptability series  and  Continuous Environmental Tracking, which have since led to claims about immanent selection. Their claims failed to link natural selection for energy-dependent codon optimality (fixation of food energy-dependent pheromone-controlled amino acid substitutions) to the prevention of all diseases via internal trait selection in Engineered Adaptability: Trait Selection Is Internal, Not External (1/31/19)

Engineered adaptability is included in what is known about the Circular RNA Control of Vascular Smooth Muscle Cell Functions (2/14/19)

Circular RNAs (circRNA) are generated by an alternative RNA splicing process called backsplicing, in which a splice donor is spliced to an upstream acceptor thereby resulting in the formation of an RNA loop that is stably expressed. CircRNAs initially have been described in the 90s, but only recently computational analysis suggested that circRNAs are more prevalent than initially thought. Several studies have reported on regulatory activities in different biological processes, including the control of angiogenesis, smooth muscle cell functions, and cardiac injury responses.1,2 Evidence so far indicates that circRNAs predominantly act as noncoding RNAs but may also encode for peptides/proteins. Towards their mechanism of action, first studies suggested that they may act as microRNA (miRNA, miR) sponges preventing the biological activity of these small noncoding RNAs. However, circRNAs have also been shown to control transcription, bind to proteins and other RNAs thereby interfering with multiple effector pathways.

The facts about circular RNA control of alternative splicing of pre-mRNA, now referred to as microRNAs have been linked from L-ANC to the prevention of all diseases or from the virus-driven degradation of messenger RNA to all pathology, since 1996: See our section on molecular epigenetics in this review of cell-type differentiation From Fertilization to Adult Sexual Behavior.

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

You may not have learned anything about alternative splicings because the fact that they are energy-dependent and biophysically constrained refutes the pseudoscientific nonsense touted by theorists. They don’t want to loose their stranglehold on scientific progress, so they play word games.

For example, alternative splicings of pre-mRNAs (microRNAs) were placed into the context of nonhomoloous end joining

Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining 9/14/18

Reported as: RNA takes over DNA repair

They found that RNA is routinely incorporated during the repair of DNA double-strand breaks through the mammalian nonhomologous end–joining (NHEJ) pathway.

Serious scientists have known since 1996 that energy-dependent biophysically constrained RNA-mediated DNA repair links natural selection for energy-dependent codon optimality from the light-activated assembly of the nucleic acid-microRNA-peptide nanocomplex (L-ANC) to all biodiversity via the physiology of reproduction in species from microbes to humans.

See also, these tweets and 12.5K others @microRNApro, which are being ignored: “… how to improve specificity on detecting miRNAs…” Light-activated miRNA biogenesis links olfaction to prevention of all diseases Olfaction Warps Visual Time Perception “immanent selection”

ICR took this mouse-to-human model of natural selection to its stated conclusion via fixation of the EDAR V370A variant in human populations in the New World and the Old World …Ecological Adaptations: From Angstroms to Ecosystems

When you see others invent a new term (immanent selection for natural selection) or (non-homologous end joining for alternative splicing) you know they are trying to catch up to the researchers in China who reported!divAbstract Alternatively, plagiarists are theorists

Code implies a coder. ‘RNA World’ Paper Retracted: #Science #Research

You can’t handle the proof! Researchers from China have linked everything known about light-activated coding to biophysically constrained viral latency and the cure for cancer, and all other diseases.!divAbstract

The cure for cancer was reported by researchers from Israel. Researchers from Iran confirmed the link from effective treatment to the cure:

ICR erred on the side of caution because there was no proof that the virus-driven degradation of messenger RNA caused all diseases that have arisen during the past 5-10K years. See: “Past 5,000 years prolific for changes to human genome”

Now that the proof has been verified by all serious scientists in every part of the world, ICR has changed natural selection to immanent selection to avoid or to add more confusion to claims about Darwinism or neo-Darwinism. See:

Biologically uninformed theorists, philosophers, and atheists hate the fact that they missed what others placed into the context of coding for supercoiled DNA before they started to make fun of pseudoscientists. For comic relief, see:

Feynman wasn’t joking when he claimed that other theoretical physicists exemplified human idiocy. This may seem cruel, but the unnecessary suffering and premature deaths of millions exemplify the ultimate cruelty.

Henry Morris IV complained that I tend to hijack his discussion attempts on FB before he blocked me from seeing them. Now we see other reports of hijacking claims from the Holy Bible by those who tout ridiculous theories from population genetics. See:

See also: “…parasitic genomic elements… hijack a host developmental process to propagate robustly, thereby driving evolutionary change and causing disease.”
Many polymaths have linked facts such as these to the hecatombic evolution of disease.

Find a polymath who believes energy emerged from nothing and the emergence led to the evolution of all biodiversity under the sun. Invite that polymath to enter debate with me, or with Ben Feringa. Bill Nye lost against Ken Ham, who ensured other losses.

Author: James Kohl

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