Do not call me Ishmael (4)

Summary: This interaction links the food energy-dependent pheromone-controlled creation of enzymes and receptors to biophysically constrained viral latency via the amino acid substitutions that differentiate all cell types in all individuals of all living genera.

CD4 receptor diversity in chimpanzees protects against SIV infection (2/4/19)

Reported as: Diversity in the CD4 receptor protects chimpanzees from infection by AIDS-like viruses

…chimpanzees have evolved several mutations in this CD4 domain that blocks this interaction…

The team found that these mutations include amino acid changes in contact residues as well as the addition of bulky sugar molecules, called glycans, at the CD4-envelope binding interface. “Glycans on the chimpanzee CD4 clash with glycans on the SIV envelope, which impedes virus entry into the cell,” said co-first author Frederic Bibollet-Ruche, Ph.D., a research assistant professor of Microbiology in Hahn’s lab. This type of glycan-glycan interaction has not been seen before as an anti-viral mechanism”.

This interaction links the food energy-dependent pheromone-controlled creation of enzymes and receptors to biophysically constrained viral latency via the amino acid substitutions that differentiate all cell types in all individuals of all living genera.

This team does not seem to know the difference between an amino acid substitution and a mutation. They must all be biologically uninformed science idiots who got their example of human idiocy past the reviewers at PNAS.

Do you know how peptides (chains of amino acids) are created? See for comparison:

Researchers may have solved origin-of-life conundrum

…the conditions that produce nucleic acid precursors also create… natural amino acids and lipids. That suggests a single set of [light activated] reactions [gave] rise to most of life’s building blocks simultaneously.

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Author: James Kohl

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