Summary: For review of cell biology see “Cytosis.” “Subatomic” will link the creation of subatomic particles to the fixation of the EDAR V370A variant in human populations in the New World via what populations in North and East Asia eat and their pheromone-controlled physiology of reproduction. Until then, see this pseudoscientific nonsense about evolution.
Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica
Our finding of endogenous stochastic decoding by competing tRNAs provides the first example of a living species where the proteome cannot be deterministically predicted from the genome.
Quantized energy-dependent changes in the creation of microRNAs link light-activated endogenous substrates to all extant biodiversity via the physiology of pheromone-controlled reproduction and biophysically constrained RNA-mediated fixation of amino acid substitutions in the organized genomes of all living genera. The fixation of RNA-mediated amino acid substitutions protects all organized genome from the virus-driven degradation of messenger RNA, which serious scientists have linked to all pathology.
See for comparison: Are Space And Time Quantized? Maybe Not, Says Science
…we need more information before we truly know what our Universe is up to at a fundamental level.
The concept of quantized energy as information that protects all organized genomes from the virus-driven degradation of messenger RNA was represented in this review of nutritional epigenetics.
See: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems
Concluding paragraphs:
The plausibility and ecological validity of Kohl’s Laws in the context of Darwin’s ‘conditions of life’ can be compared to theories about biologically-based cause and effect in the context of species diversity. In mammals, for example, the explanatory power of a model of ecological variation and biophysically constrained nutrient-dependent pheromone-controlled ecological adaptations became clear with companion papers published in 2013. See for review [26].
The companion papers [159,160] told a new short story of ecological adaptations. In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China. Apparently, the effect of the epiallele was adaptive and it was manifested in the context of an effect on sweat, skin, hair, and teeth. In another mammal, such as the mouse, the effect on sweat, skin, hair, and teeth is probably due to a nutrient-
dependent epigenetic effect on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones.
The pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated. The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [159,160]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to
ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.
159. Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, et al. (2013) Modeling
recent human evolution in mice by expression of a selected EDAR
variant. Cell 152: 691-702.
160. Grossman SR, Andersen KG, Shlyakhter I, Tabrizi S, Winnicki S, et al.
(2013) Identifying recent adaptations in large-scale genomic data. Cell
152: 703-713.
See for comparison: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk
We hypothesize that selection on EDAR V370A occurred in the Beringian refugium because it increases mammary ductal branching, and thereby may amplify the transfer of critical nutrients in vitamin D-deficient conditions to infants via mothers’ milk. This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids.
Moving forward “Olfaction Warps Visual Time Perception” links energy-dependent microRNA biogenesis from the creation of the sense of smell in bacteria across the space-time continuum to our visual perception of energy and mass.
See for review of cell biology: “Cytosis”
Watch for the follow-up for ages 10+. “Subatomic” links the creation of subatomic particles to the fixation of the EDAR V370A variant in human populations in the New World via what populations in North and East Asia eat and their pheromone-controlled physiology of reproduction.
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.