The biochemical basis of microRNA targeting efficacy Posted September 11, 2018 as a bioRxiv preprint by David Bartel’s group.
One feature that was not captured in our model is the evolutionary conservation of sites…
Translation: Their model refutes every aspect of neo-Darwinian nonsense and Big Bang cosmology. The creation of sunlight has been linked from microRNA biogenesis to viral latency and all biophysically constrained biodiversity via all serious scientists. I retweeted the report on The biochemical basis of microRNA targeting efficacy many times, and there was no discussion of my comments. Typically, discussion might have occurred on Disqus, but bioRxiv blocks or removes most of them them.
See instead: Predicting microRNA targeting efficacy in Drosophila, published by David Bartel’s group on October 4, 2018 as an insect model that is used to extend findings to humans via the food energy-dependent pheromone-controlled physiology of reproduction.
These new insights and resources are anticipated to enhance the productivity of miRNA research in flies and thereby accelerate the understanding of this intriguing class of regulatory RNAs.
More than 79,000 published works link “this intriguing class of regulatory RNAs” to every aspect of biophysically constained viral latency and the prevention of all pathology.
See: microRNA
See also: Adolescent brain development impacts mental health, substance use Nov 5, 2018
New findings offer promising avenues for early therapeutic interventions in young people
The findings are not new; they have been buried in the extant literature in ways that most people cannot understand. Early therapeutic interventions must be microRNA-mediated in the context of biophysically constrained RNA interference.
See also, “Childhood trauma impacts the development of critical brain networks during adolescence, elevating the risk for alcohol abuse” (Sarita Silveira, PhD, abstract 645.04) was scheduled for presentation on Nov 7, 2018. Reporting the findings in advance, seems inappropriate, since conference presentations may be withdrawn, or the presenters may not show up if they fear ridicule from serious scientists.
But see:
Results from this study will significantly advance the understanding of how functional network development during adolescence contributes to alcohol and substance abuse. This research also has the potential to inform network-targeted therapeutics for individuals with childhood trauma.
For comparison to all attempts to promote drug development, here is an example of what is known about biophysically constrained RNA interference.
The fact that one energy-dependent base pair change and fixation of one RNA-mediated amino acid substitution and the pheromone-controlled physiology of reproduction in humans could prevent school shootings and other gun violence does not appear to be included in most of the preprints published to servers such as bioRxiv.
My comment on that fact led to this sarcastic comment from the Assistant Director of Cold Spring Harbor Laboratory Press, Editor of CSH Perspectives, and bioRxiv Co-Founder Richard Sever, who seems to think that the book “Innate” by Kevin J. Mitchell exemplified something more than a display of human idiocy for comparison to the reports on microRNAs.
Thanks for your readily expected sarcasm. He is only one among many popular pseudoscientists from the academic cult who tout nonsense that is believed by most of those submitting preprints to bioRxiv, where most of my comments are blocked. See for example: https://t.co/L1L4E3HCR4
— James V. Kohl (@jvkohl) November 6, 2018
Despite the scientific progress exemplified on October 4, 2018 in Predicting microRNA targeting efficacy in Drosophila, which used an insect model to extend findings to humans via the food energy-dependent pheromone-controlled physiology of reproduction bioRxiv published another preprint on the “…evolution of complex nervous systems.” If enough ridiculous claims about evolution continue to be made, will pseudoscientists ever be forced to learn about microRNAs?
Richard Sever’s @cshperspectives responded sarcastically to my claim that @WiringTheBrain was attempting to influence the US mid-term elections by touting pseudoscientific nonsense about evolution. That claim can be placed into the context of Johannes Kohl’s reward for his failure to link “Neural control of parental behaviors” to biophysical constraints on viral latency.
For comparison, those who have followed my works and the works of Bruce McEwen on stress-linked pathology published: Olfaction Warps Visual Time Perception They linked the sense of smell in bacteria to the physiology of reproduction and all biodiversity in the context of the space-time continuum.
George Church et al. did that with this patent for naturally occurring RNA interference: RNA-Guided Human Genome Engineering.
Richard Sever and others like him seem to think they can stop intelligent people from realizing that the Trump administration aborted this “billion dollar baby” in naturally occurring therapy. The proposed therapy is too expensive an option for most people.
Until now, most members of the “academic cult” have stonewalled me. When they deliberately attack, they are faced with the claims of scientific creationists, which were presented before the end of the day on Nov 6, 2018 #SFN18 “A noble finding of miRNAs in neurogenic differentiation…”
Scientific creationists from South Korea have linked the creation of sunlight to biophysically constrained viral latency via ATP-dependent microRNA biogenesis, the creation of RNA, the physiology of pheromone-controlled reproduction and the addition of the NIH to the Church et al. patent for biophysically constrained neurogenic differentiation.
See the update: RNA-Guided Human Genome Engineering
Owner name: NATIONAL INSTITUTES OF HEALTH (NIH)
A Senate Committee Investigation will almost undoubtedly drain the academic swamp. Republicans won the mid-terms. But biologically uninformed God-less Democrats kept control of the House. That means the ongoing threat posed to Homeland Security by Cold Springs Harbor can still be viewed in the context of this interview.
Clearly, the viruses carried by the Honduran Horde, which is still approach the border of the USA, threaten us all. For a historical perspective on Cold Springs Harbor’s involvement in the ongoing threat, see
The Interactions of Retroviruses and their Hosts (1997) as cited in The Darwin Code by Greg Bear who is exemplified in this quote.
“Talent hits a target no one else can hit. Genius hits a target no one else can see.” — Arthur Schopenhauer
See also: Evolution of retroviruses: fossils in our DNA. Reported as: Ancient Retrovirus Is Resurrected
Retroviruses do not evolve. The stress-linked reactivation of viruses in all organized genomes has been linked from the Virus-mediated archaeal hecatomb in the deep seafloor from virus-driven energy theft to the virus driven degradation of messenger RNA that links mutations to all diseases.
Would you like to prolong the energy-dependent life of some or all of your cells and teach your offspring how to survive the next viral pandemic?
If so, learn something about biophysically constrained DNA repair. See for instance:
[Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] (1994)
A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.
See also: A Bidirectional Circuit Switch Reroutes Pheromone Signals in Male and Female Brains (Johannes Kohl et al., December 19, 2013)
See also: A Novel Cell Death Gene Acts to Repair Patterning Defects in Drosophila melanogaster (March 25, 2014)
Luca Turin’s works link quantum physics to consciousness via the energy-dependent creation of olfactory receptor genes in this model organism. Food energy biophysically constrains viral latency in the context of the pheromone-controlled physiology of reproduction in species from microbes to humans, but molecular recognition begins with the creation of the sense of smell in bacteria.
See also: Molecular recognition in olfaction
Vibrational Detection of Odorant Functional Groups by Drosophila Melanogaster
The vibrational theory of olfaction for the win
The energy-dependent creation of the sense of smell in bacteria has since been linked to virus-driven RNA uridylation and decay in plants
This article is part of the theme issue ‘5’ and 3′ modifications controlling RNA degradation
For the link from prevention of the virus-driven degradation of messenger RNA in plants to cancer prevention see: Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats
Naturally occurring RNA interference via Zn supplementation may prevent a leading cause of cancer death in men over 50 years of age.
For link from what people eat to biophysically constrained viral latency and the prevention or effective treatment of all neurodegenerative disorders, such as Alzheimer’s, see:
In my model, the virus-driven degradation of messenger RNA is linked to all pathology and food energy-dependent RNA-mediated amino acid substitutions link sunlight from microRNA biogenesis to healthy longevity via the physiology of reproduction.
For comparison to everything known to serious scientists about biophysically constrained energy-dependent viral latency and cell type differentiation in all living genera, see my review of Innate:
Ignoring light-activated microRNA biogenesis
In a way, all intelligent people may be thankful for the misrepresentations of biophysically constrained top-down causation made by Kevin J. Mitchell and others who exemplify human idiocy. Only via their attempts to pervert the scientific facts can others see that the facts are clearly represented at every level of biological organization.
How much longer will the perversion occur in the context of CSH Perspectives (BioRxiv) that promote the viral pandemic?
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Removed from BioRxiv
The biochemical basis of microRNA targeting efficacy
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.