CSH perspectives: ignore the viral pandemic

The biochemical basis of microRNA targeting efficacy Posted September 11, 2018 as a bioRxiv preprint by David Bartel’s group.

One feature that was not captured in our model is the evolutionary conservation of sites…

Translation: Their model refutes every aspect of neo-Darwinian nonsense and Big Bang cosmology. The creation of sunlight has been linked from microRNA biogenesis to viral latency and all biophysically constrained biodiversity via all serious scientists. I retweeted the report on The biochemical basis of microRNA targeting efficacy many times, and there was no discussion of my comments. Typically, discussion might have occurred on Disqus, but bioRxiv blocks or removes most of them them.

See instead: Predicting microRNA targeting efficacy in Drosophila, published by David Bartel’s group on October 4, 2018 as an insect model that is used to extend findings to humans via the food energy-dependent pheromone-controlled physiology of reproduction.

These new insights and resources are anticipated to enhance the productivity of miRNA research in flies and thereby accelerate the understanding of this intriguing class of regulatory RNAs.

More than 79,000 published works link “this intriguing class of regulatory RNAs” to every aspect of biophysically constained viral latency and the prevention of all pathology.

See: microRNA

See also: Adolescent brain development impacts mental health, substance use Nov 5, 2018

New findings offer promising avenues for early therapeutic interventions in young people

The findings are not new; they have been buried in the extant literature in ways that most people cannot understand. Early therapeutic interventions must be microRNA-mediated in the context of biophysically constrained RNA interference.

See also, “Childhood trauma impacts the development of critical brain networks during adolescence, elevating the risk for alcohol abuse” (Sarita Silveira, PhD, abstract 645.04) was scheduled for presentation on Nov 7, 2018. Reporting the findings in advance, seems inappropriate, since conference presentations may be withdrawn, or the presenters may not show up if they fear ridicule from serious scientists.

But see:

Results from this study will significantly advance the understanding of how functional network development during adolescence contributes to alcohol and substance abuse. This research also has the potential to inform network-targeted therapeutics for individuals with childhood trauma.

For comparison to all attempts to promote drug development, here is an example of what is known about biophysically constrained RNA interference.

See: Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

The fact that one energy-dependent base pair change and fixation of one RNA-mediated amino acid substitution and the pheromone-controlled physiology of reproduction in humans could prevent school shootings and other gun violence does not appear to be included in most of the preprints published to servers such as bioRxiv.

My comment on that fact led to this sarcastic comment from the Assistant Director of Cold Spring Harbor Laboratory Press, Editor of CSH Perspectives, and bioRxiv Co-Founder Richard Sever, who seems to think that the book “Innate” by Kevin J. Mitchell exemplified something more than a display of human idiocy for comparison to the reports on microRNAs.

Despite the scientific progress exemplified on October 4, 2018 in Predicting microRNA targeting efficacy in Drosophila, which used an insect model to extend findings to humans via the food energy-dependent pheromone-controlled physiology of reproduction bioRxiv published another preprint on the “…evolution of complex nervous systems.” If enough ridiculous claims about evolution continue to be made, will pseudoscientists ever be forced to learn about microRNAs?

Richard Sever’s @cshperspectives responded sarcastically to my claim that @WiringTheBrain was attempting to influence the US mid-term elections by touting pseudoscientific nonsense about evolution. That claim can be placed into the context of Johannes Kohl’s reward for his failure to link “Neural control of parental behaviors” to biophysical constraints on viral latency.

For comparison, those who have followed my works and the works of Bruce McEwen on stress-linked pathology published: Olfaction Warps Visual Time Perception  They linked the sense of smell in bacteria to the physiology of reproduction and all biodiversity in the context of the space-time continuum.

George Church et al. did that with this patent for naturally occurring RNA interference: RNA-Guided Human Genome Engineering.

Richard Sever and others like him seem to think they can stop intelligent people from realizing that the Trump administration aborted this “billion dollar baby” in naturally occurring therapy. The proposed therapy is too expensive an option for most people.

Until now, most members of the “academic cult” have stonewalled me. When they deliberately attack, they are faced with the claims of scientific creationists, which were presented before the end of the day on Nov 6, 2018 #SFN18 “A noble finding of miRNAs in neurogenic differentiation…

Scientific creationists from South Korea have linked the creation of sunlight to biophysically constrained viral latency via ATP-dependent microRNA biogenesis, the creation of RNA, the physiology of pheromone-controlled reproduction and the addition of the NIH to the Church et al. patent for biophysically constrained neurogenic differentiation.

See the update: RNA-Guided Human Genome Engineering


A Senate Committee Investigation will almost undoubtedly drain the academic swamp. Republicans won the mid-terms. But biologically uninformed God-less Democrats kept control of the House. That means the ongoing threat posed to Homeland Security by Cold Springs Harbor can still be viewed in the context of this interview.


Clearly, the viruses carried by the Honduran Horde, which is still approach the border of the USA, threaten us all. For a historical perspective on Cold Springs Harbor’s involvement in the ongoing threat, see

 The Interactions of Retroviruses and their Hosts (1997) as cited in The Darwin Code by Greg Bear who is exemplified in this quote.

“Talent hits a target no one else can hit. Genius hits a target no one else can see.” — Arthur Schopenhauer

See also: Evolution of retroviruses: fossils in our DNA. Reported as: Ancient Retrovirus Is Resurrected

Retroviruses do not evolve. The stress-linked reactivation of viruses in all organized genomes has been linked from the Virus-mediated archaeal hecatomb in the deep seafloor from virus-driven energy theft to the virus driven degradation of messenger RNA that links mutations to all diseases.

Would you like to prolong the energy-dependent life of some or all of your cells and teach your offspring how to survive the next viral pandemic?

If so, learn something about biophysically constrained DNA repair. See for instance:

[Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] (1994)

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

See also: A Bidirectional Circuit Switch Reroutes Pheromone Signals in Male and Female Brains (Johannes Kohl et al., December 19, 2013)

See also: A Novel Cell Death Gene Acts to Repair Patterning Defects in Drosophila melanogaster (March 25, 2014)

Luca Turin’s works link quantum physics to consciousness via the energy-dependent creation of olfactory receptor genes in this model organism. Food energy biophysically constrains viral latency in the context of the pheromone-controlled physiology of reproduction in species from microbes to humans, but molecular recognition begins with the creation of the sense of smell in bacteria.

See also: Molecular recognition in olfaction

Vibrational Detection of Odorant Functional Groups by Drosophila Melanogaster

The vibrational theory of olfaction for the win

The energy-dependent creation of the sense of smell in bacteria has since been linked to virus-driven RNA uridylation and decay in plants

 This article is part of the theme issue ‘5’ and 3′ modifications controlling RNA degradation

For the link from prevention of the virus-driven degradation of messenger RNA in plants to cancer prevention see:  Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats

Naturally occurring RNA interference via Zn supplementation may prevent a leading cause of cancer death in men over 50 years of age.

For link from what people eat to biophysically constrained viral latency and the prevention or effective treatment of all neurodegenerative disorders, such as Alzheimer’s, see:

Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites

In my model, the virus-driven degradation of messenger RNA is linked to all pathology and food energy-dependent RNA-mediated amino acid substitutions link sunlight from microRNA biogenesis to healthy longevity via the physiology of reproduction.

For comparison to everything known to serious scientists about biophysically constrained energy-dependent viral latency and cell type differentiation in all living genera, see my review of Innate:

Ignoring light-activated microRNA biogenesis

In a way, all intelligent people may be thankful for the misrepresentations of biophysically constrained top-down causation made by Kevin J. Mitchell and others who exemplify human idiocy. Only via their attempts to pervert the scientific facts can others see that the facts are clearly represented at every level of biological organization.

How much longer will the perversion occur in the context of CSH Perspectives (BioRxiv) that promote the viral pandemic?


Removed from BioRxiv

The biochemical basis of microRNA targeting efficacy


Attempts to start discussions here seem to be as futile as attempts to teach others about seemingly futile cycles of energy-dependent autophagy.

From one month ago: Diverse endogenous retroviruses generate structural variation between human genomes via LTR recombination


RE: “These data indicate that human proviral content exhibit more extensive interindividual variation than previously recognized. These findings have important implications for our understanding of the contribution of HERVs to human physiology and disease.”

Extrapolation of their data for use in my model also links the creation of sunlight from microRNA biogenesis to biophysically constrained viral latency in all living genera. The
physiology of pheromone-controlled reproduction in species from microbes to humans during the past ~6000 years is linked to partial protection from the virus-driven degradation of messenger RNA. Serious scientists have linked the degradation of messenger RNA from mutations to all pathology. Pseudoscientists and other theorists have linked the
mutations to evolution.
Bartel’s group addressed the difference between pseudoscientists and serious scientists in this preprint. Do you know why BioRxiv would not want discussion of that fact?

Removed from BioRxiv

This highly significant somewhat cloaked advancement of a “new scientific truth” follows on the well-worn heels of McEwen et al (1964), whose tracks can help put these findings into perspective. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” https://www.sciencedirect.c…

Anyone who did not start with the ATP-dependent microRNA-mediated creation of RNA has failed to link the creation of sunlight from microRNA biogenesis in plants to biophysically constrained viral latency and all biodiversity via the physiology of reproduction. You can already see how this will play out by linking the findings from Bartel’s group to this report in Science Magazine: Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining http://science.sciencemag.o…

If you remember that RNA-mediated DNA repair is quantized energy-dependent, you are less likely to be fooled by theorists. They reported an “Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes” http://science.sciencemag.o… “Using electron microscopy, we determined the atomic structure of a highly divergent ribosome found in mitochondria of Trypanosoma brucei…”

Unless the atomic structure automagically “emerged” and “evolved,” divergent ribosomes found in the mitochondria must be reported in the context of claims about light-activated microRNA biogenesis. That explains the long-awaited claim by Bartel’s group that refutes the pseudoscientific nonsense touted by neo-Darwinian theorists.

ICYMI “One feature that was not captured in our model is the evolutionary conservation of sites…”



Author: James Kohl

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