Cross species transfer of genes and ecological adaptation

Horizontal transfer of BovB and L1 retrotransposons in eukaryotes

Contrary to the belief of exclusive vertical inheritance, our results with L1s suggest multiple ancient HT events in eukaryotes, mainly among aquatic species, and possible HT into the early therian mammal lineage. The rapid speciation following the split of theria and australosphenids (monotremes), 160–191 MYA, coincides with the invasion of L1 elements into therian genomes. We therefore speculate that the speciation of therian mammals was driven in part by the effect of L1 retrotransposition on genome structure and function, including regulatory effects on transcriptional networks. This ancient transfer event allowed expansion of L1s and associated SINEs, transformation of genome structure and regulation in mammals [45], and potentially catalysed the therian radiation.

Reported as:  Cross species transfer of genes has driven evolution

The transfer is quantized energy-dependent and food energy biophysically constrains viral latency. That is not evolution.

It exemplifies how ecological variation must be linked from what organisms eat to ecological adaptations via changes in base pairs and fixation of RNA-mediated amino acid substitutions. Fixation occurs in the context of the physiology of pheromone-controlled reproduction in species from microbes to humans.

In P. fluorescens, adaptation was linked to the energy-dependent weekend resurrection of the bacterial flagellum. (video)

See also: Evolution And The Fabled Mutations – THE TRUTH

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection…

The bout of positive selection links natural selection for energy-dependent codon optimality from food energy-dependent changes in base pairs and to the pheromone-controlled fixation of amino acid substitutions such as EDAR V370A that stabilize the organized genomes of species from microbes to humans in the context of what is known to all serious scientists about the microRNAome.

The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression (2014)

See also: From Fertilization to Adult Sexual Behavior (1996) and Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)

In my 2018 review of nutritional epigenetics, I linked the quantized energy-dependent pheromone-controlled EDAR V370A variant to the stability of all organized human genomes in the context of Dobzhansky’s creationist claims in Nothing in Biology Makes Any Sense Except in the Light of Evolution.

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

See also: Single-cell isoform RNA sequencing (ScISOr-Seq) across thousands of cells reveals isoforms of cerebellar cell types

Isoform-expression in all cell types of all individuals of all species is quantized energy-dependent and RNA-mediated. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Without the ATP-dependent synthesis of RNA, you cannot get from isoform expression to biophysically constrained RNA-mediated DNA repair and cell type differentiation.

Author: James Kohl

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