Summary: See: The biochemical basis of microRNA targeting efficacy and Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining science. The preprint and the published article from Science are available for free. They link the light-activated creation of microRNAs from the creation of sunlight to biophysically constrained viral latency. Taken together, they refute neo-Darwinian nonsense and Big Bang cosmology in their entirety by linking microRNA biogenesis to the physiology of pheromone-controlled reproduction in the context of Biblical Genesis and our visual perception of energy and mass in the context of the space-time continuum.
On September 11, 2018, David P Bartel’s group linked light-activated microRNA biogenesis in plants to biophysically constrained viral latency and all biodiversity via the physiology of pheromone-controlled reproduction in species from soil bacteria to primates.
On September 14, 2018 Science Magazine published A pinch of RNA spices up DNA repair
…cells have evolved efficient ribonucleotide removal strategies that rely on ribonuclease H2 (RNase H2) (2). … Pryor et al. (3) report the surprising discovery that ribonucleotides are frequently incorporated at broken DNA ends, which enhances repair. This important finding overturns the central dogma of molecular biology by demonstrating that transient incorporation of ribonucleotides in DNA has a biological function.
No serious scientist ever believed in the pseudoscientific nonsense about the evolution of quantized energy-dependent ribonucleotide removal strategies. The removal strategies require the biophysically constrained creation of enzymes such as ribonuclease H2 and energy-dependent autophagy. See: Autophagy.pro
Although he knew nothing about any of this, Darwin presciently put the creation of enzymes first when he tried to ensure that others would not bastardize his claims about “conditions of life.” Conditions of life are energy-dependent. For example, finches and/or pigeons who starve to death leave no offspring. That’s why the offspring cannot create enzymes that cause them to mutate and be naturally selected to evolve into other species.
Simply put, pseudosceintists bastardized all of Darwin’s claims when they invented neo-Darwinism by putting natural selection first.
Beneficial roles for ribonucleotide incorporation in DNA have been identified previously (13). For example, ribonucleotide incorporation in DNA was implicated in mating-type switching in yeast…
The citation to How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells (2014) skips past everything that was known to all serious scientists about biophysically constrained cell type differentiation in yeasts at the time we linked the pheromone-controlled physiology of reproduction in species from microbes to humans in our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior (1996).
In our section on molecular epigenetics from 18 years ago, we wrote:
Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.
In our “Discussion” section, we added:
Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus (Runge and Zakian, 1996; Wu and Haber, 1995).
Biologically uninformed theorists have since tried and failed to cope with the claims about epigenetic modifications in the context of Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk. The claims link one base pair and one amino acid substitution to differences in mice and humans compared to human populations in North and East Asian and in the New World.
See also: Olfaction Warps Visual Time Perception