Creation of an enzyme that kills theories (3)

Summary: Yesterday, the pseudoscientific nonsense touted by biologically uninformed population geneticists was placed into the context of the #ASHG18 Presidential address.

Previously: Light-activated microRNA biogenesis in plants has been linked from autophagy to protection from the virus-driven degradation of messenger RNA, which links mutations to all pathology.  See: Theorists: The biggest threat to microRNA-mediated security (9/21/18)

Light-activated microRNA biogenesis in plants links the energy-dependent creation of enzymes, ATP, and RNA to food energy-dependent autophagy. Autophagy protects organized genomes from the virus-driven degradation of messenger RNA. If the energy required for the creation of RNA is used by viruses, organisms that fail to adapt to ecological variation are doomed.

For example, see: MicroRNA 200c-3p regulates autophagy via upregulation of endoplasmic reticulum stress in PC-3 cells (1/3/18) with my emphasis

CONCLUSIONS: Overall, our findings suggest that miR-200c-3p regulates autophagy via upregulation of ER stress signaling.

Their suggestion can be placed into the context of what ages 10+ could learn about cell type differentiation and ecological adaptations by playing Cytosis: A Cell Biology Board Game 

Players compete to build enzymes, hormones and receptors and fend off attacking Viruses! (2 to 5 Players, Ages 10 & up, Plays in 50 to 75 mins)

The science behind the game (free download) is the four page booklet that was written and edited collaboratively by 20 experts from through the world. (pdf)

 In the Virus Expansion, three different strains of virus cards are added to the game – Ebola virus, Influenza, and Rhinovirus. When any of these cards become active, it initiates a “virus attack” and may cause players to lose resources and health, just as we do when we get sick.

For a real-life example of what must happen to protect organized genomes from a “virus attack,” see: ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication 10/15/18

ADP ribosylation of proteins and nsP3^MD ADPr binding are necessary for initiation of alphavirus replication, while hydrolase activity facilitates amplification of replication complexes. These observations are consistent with observed nsP3^MD conservation and limited tolerance for mutation.

The food energy-dependent limitations on viral replication  have been linked to the limited tolerance for mutations in viruses and in people. There is no mention of that fact in the context of mosquito-borne RNA viruses that cause encephalitis, rash, and arthritis and this claim: “…miR-200c-3p regulates autophagy via upregulation of ER stress signaling.”

The limited tolerance for mutations in viruses and/or all cell types contributes to the mutation-driven evolution of all diseases or links what organisms eat to the physiology of reproduction and the transgenerational epigenetic inheritance of healthy longevity via the claims in our 1996 review of RNA-mediated cell type differentiation: From Fertilization to Adult Sexual Behavior

Pseudoscientists know that they can distract the biologically uninformed masses via examples like those found in the history of publications by Kevin J. Mitchell. The historical record led to his bastardization of everything known about light energy-dependent microRNA biogenesis and biophysically constrained viral latency in Innate How the Wiring of Our Brains Shapes Who We Are

See my review of Kevin J. Mitchell’s book: Ignoring light-activated microRNA biogenesis

He frames his claims in the context of random mutations and evolved biodiversity despite the facts that serious scientists have detailed. For example, ages 10+ can learn how the creation of subatomic particles must be linked from cytosis to biophysically constrained viral latency and sympatric speciation.

The physiology of reproduction is linked to heredity in species from soil bacteria to humans via EDAR V370A (an amino acid substitution) in mice; in populations found in North and East Asia; and in populations in the New World.

I could go on about the facts about cell type differentiation for hours or refer you to MicroRNA.pro or one of my other domains. Alternatively, you could see the work that was published today: “MicroRNAs buffer genetic variation at specific temperatures during embryonic development” for comparison to our 1996 review of molecular epigenetics: “From Fertilization to Adult Sexual Behavior”

The comments have already been linked to the Trump administration’s attempt to drain the academic swamp.

Amazon Customer

Congratulations, Mr. Kohl on winning the Donald J Trump award for the most unintelligible word salad in a review.

Thanks. I didn’t know that there was any award for serious scientists who tell the truth about how virus-driven energy theft is linked to all pathology. Perhaps that is because all serious scientists and Donald J Trump already know that you — and others like you — do not want to know the truth.

Please read the book and submit your review for criticisms by serious scientists and/or members of the Trump administration if you want this to be the start of another political battle, or Senate Investigation of lies told by greedy researchers and politicians.

Thanks. I mentioned that “MicroRNAs buffer genetic variation at specific temperatures during embryonic development.” They protect the embryo from the virus-driven degradation of messenger RNA that serious scientists have linked from mutations to all pathology, including the pathology linked to the transgenerational epigenetic inheritance of diseases via the tobacco mosaic virus. Virus-damaged DNA can be compared to what happens via light-tracking in Brugmansia. The light-tracking is linked to healthy longevity via the physiology of pheromone-controlled reproduction in soil bacteria and food energy in all living genera.

I don’t think I can add links to the research results on the Amazon book review site, but see:

Progressive aridification in East Africa over the last half million years and implications for human evolution

…correlations have proved to be difficult, given poor data continuity and the great distances between marine cores and terrestrial basins where fossil evidence is located.

Reported as: Drier, less predictable environment may have spurred human evolution

For comparison, see the link to ecological adaptation in plants and ask “What did the evolved humans eat?”

Combinations of Small RNA, RNA, and Degradome Sequencing Uncovers the Expression Pattern of microRNA(-)mRNA Pairs Adapting to Drought Stress in Leaf and Root of Dactylis glomerata L

…we explored the… miRNAs that may be involved in drought adaptation… and identified how they may be regulated.

All intelligent people know that sunlight on contact with water regulates microRNA (miRNA) biogenesis and that is how virucidal light is linked to ecological adaptations.

Search the ASHG18 webplanner entries for “miRNA” to find the presentations that link light-activated microRNA biogenesis to biophysically constrained viral latency and all biodiversity via the physiology of reproduction in soil bacteria and light-tracking Brugmansia.

See for example, search for: “petrov”

Machine learning of ultra-deep whole-genome sequencing of human brain reveals somatic retrotransposition in both neurons and glia.

This study shows for the first time that genomic mosaicism by retrotransposons can manifest also in glia…

[The link from virus-driven activation of the “death gene” to glioblastoma was obvious in the 2011 publication of Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene]

For the truth about prevention, search for: “natural selection”

…cataloging common variation from each… extant primate species would” [link food energy-dependent amino acid substitutions]… to… most of the… benign positions in the human genome… [via what is known about viral latency].

To place the facts into context, it helps to know that the tobacco plant is a relative of Brugmansia. Also, Rosalind Franklin presciently linked the tobacco mosaic virus from the virus-driven degradation of messenger RNA to all pathology. Welcome her back so that everyone can ridicule the population geneticists who are presenting at the American Society of Human Genetics annual meeting (#ASHG18) The ridicule started several years ago. See:

See the #ASHG18 search results for: “evolution”

A limited set of transcriptional programs define major histological types and provide the molecular basis for a cellular taxonomy of the human body.

…our inferred cellular composition precisely defines tissue type and captures morphological heterogeneity in the samples. We identified changes in the cell type composition occurring with age and sex in a few tissues. We found that departures from the normal cellular composition of tissues correlate with histological phenotypes associated to diseases. Alterations of the cellular composition are particularly relevant in cancer, where they can be even associated to different stages of disease progression. The collection of primary cells transcriptomes produced here is a unique resource to understand tissue biology, serving as interface between tissue and single cell transcriptomics.

Food energy-dependent biophysically constrained viral latency links light-activated microRNA biogenesis fromRNA-mediated amino acid substitutions to the interface between single cell transcriptomics and species-specific tissue types in all individuals of all species.

See: MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination

…better understanding of the transitions into and from the hybrid phenotype holds promise for a better comprehension of cancer progression. It can also help to address long-standing fundamental questions linked to compelling clinical needs—how to distinguish between the aberrant dynamics of epithelial–hybrid–mesenchymal transitions during tumorigenesis vs. the normal programs of embryonic development and tissue regeneration. Of practical importance is the requirement that pregnancy and normal wound healing must continue during antimetastatic therapies, and wound healing augmentation must not promote metastasis if a malignancy is present (42).

Unfortunately, most of the people attending #ASHG18 do not seem to know anything about biophysically constrained viral latency. They are probably at least a decade behind the extant literature. See for example: Seeking the foundations of cognition in bacteria: From Schrödinger’s negative entropy to latent information

…Schrodinger proposed that life required the consumption of negative entropy, that is, the use of thermodynamic imbalances in the environment. From the perspective of thermodynamics, each bacterium can be viewed as a complex system that is composed of an “engine” that uses imbalances in the environment to do work, and a “machine” that uses this energy (to act against the natural course of entropy increase) for the synthesis of organic substances.13 A third information-processing system is also needed for the coordination and synchronization of the functioning of the engine and the machine. Namely, a living cell is analogous to a complex man-made cybernetic system, or a “chimera,” composed of information processing systems and of at least two thermodynamic elements. In addition, using the outer membrane, cells sense the environment.

We proposed that, besides “negative entropy,” organisms sense the environment to extract latent embedded information.13 By latent information we refer to data embedded in the environment that, once processed cognitively, initiates change in the organism’s function or behavior. Information induces changes; hence it can be used to generate an internal condensed description (model or usable information) of the environment, which guides the organism’s functioning.