Constraints on mutational drift

A Strategy for Modulation of Enzymes in the Ubiquitin System Subscription required Published Online January 3 2013 Science DOI: 10.1126/science.1230161

Article excerpt: “…the extreme sequence conservation of ubiquitin is likely dictated by the constraints of low affinity interactions with hundreds of partners, few if any of which can tolerate mutational drift toward higher affinity interaction.”

My comment to the Science site: Does this not clearly state that mutations are extremely unlikely and that they are also not likely to be adaptive? For contrast, what prevents acceptance of the fact that adaptive evolution is nutrient chemical-dependent and pheromone-controlled via epigenetic effects on the microRNA / messenger RNA balance?

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Author: James Kohl

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