Post-transcriptional regulation, mRNA translation, Splicing, mRNA localization, Development, Epigenetic, Biophysics, Ecology, Variant, Constraint, Adaptation, Vitamin, Nutrient, Species, Diversity, RNA structure, RNA folding, High-throughput biophysics, RNA tertiary structure, nucleic acid thermodynamics
Robin Gutell presciently asked: Are you aware of any enzymatic exchange between two different RNA basepair types (e.g. G:C <> A:U) at a specific position in a structured RNA (e.g. tRNA, rRNA)? The usual explanation for the evolution of base pair types at each base pair position in a structured RNA is a collection of random mutations that initially creates a non-canonical base pair (from a canonical bp) followed by another random mutation that re-creates a canonical base pair.
I’m not familiar with exchanges that do not link ATP synthase from the energy-dependent creation of microRNAs to all other enzymatic exchanges between RNA basepair types (e.g. G:C <> A:U), The changes in RNA basepair types are liked to to biophysically constrained viral latency and to all morphological and behavioral phenotypes in species from microbes to humans via the physiology of pheromone-controlled reproduction.
I’m not sure why anyone might want to find an enzyme that might do the same thing as ATP synthase in the context of linking the sun’s anti-entropic virucidal energy from the creation of ATP and the creation of RNA to healthy longevity and all biodiversity. I also suspect that Robin Gutell predicted my answer and avoided the need to ask his question in a public forum. The best of my mentors asked me questions before telling me what they could do to help me find more answers. Then, for example, the late Robert L. Moss told me to “write the book.”
The rest is “history.” The Scent of Eros: Mysteries of Odor in Human Sexuality (1995/2002) review by Mark Sergeant
Serious scientists recognize patterns in light harvesting technology that link femotosecond blasts of UV light to RNA-mediated DNA repair and the physiology of reproduction in species from microbes to humans.
Please consider what biologically uninformed theorists could accomplish if they linked light harvesting in E.coli to the ability of P. fluorescens to resurrect the bacterial flagellum over the weekend via the biophysically constrained physiology of pheromone-controlled reproduction.