Combating ignorance to fight disease (1)

Conditions of life require the energy-dependent creation of RNA.

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

The light-activated fixation of carbon links the ATP-dependent synthesis of RNA to all biophysically constrained biodiversity via RNA interference

See: Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism (2015)

…precursors of ribonucleotides, amino acids and lipids can all be derived by the reductive homologation of hydrogen cyanide and some of its derivatives… all the cellular subsystems could have arisen simultaneously through common chemistry. The key reaction steps are driven by ultraviolet light….

Ultraviolet light kills viruses. That claim supports the claim that all cellular subsystems could have arisen simultaneously, which is the only known link to Schrodinger’s claims from 1944 in What is Life?

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.)

The creation of the sun’s anti-entropic virucidal energy was linked to the genesis of biodiversity via A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation (2018)

…plants alter microRNA (miRNA) biogenesis in response to light transition.

The light transitions were linked to the assembly of a multi-protein assembly, called human miRISC.

Phase Transitions in the Assembly and Function of Human miRISC (3/22/18)

miRISC is a multi-protein assembly that uses microRNAs (miRNAs) to identify mRNAs targeted for repression. Dozens of miRISC-associated proteins have been identified, and interactions between many factors have been examined in detail. However, the physical nature of the complex remains unknown.

Evidence that protein-mediated phase separation can facilitate an RNA processing reaction links the creation of achiral glycine to cell type differentiation across kingdoms via fluorescence in bacteria and light-activated microRNA biogenesis in plants.

For example: Evolution of gonadotropin-releasing hormone (GnRH) structure and its receptor

It is very surprising and fascinating that the coordinated evolutionary selection of amino acids participating in binding GnRH has resulted in such perfection, that no substitution with a natural amino acid in any position improves binding potency.

Natural selection for energy-dependent codon optimality links the creation of amino acids from RNA interference to healthy longevity in all living genera via the physiology of reproduction.

See also: MicroRNAs and Their Regulatory Roles in Plant-Environment Interactions (3/8/19)

In this review, we present and discuss recent updates on the mechanisms and regulation of miRNA biogenesis, miRISC assembly and actions as well as the regulatory roles of miRNAs in plant developmental plasticity, abiotic/biotic responses, and symbiotic/parasitic interactions.

The link from light-activated microRNA biogenesis in plants to human miRISC assembly  links the energy-dependent creation of achiral glycine to the the regulatory roles of miRNAs in plant developmental plasticity, abiotic/biotic responses, and symbiotic/parasitic interactions via the biophysically constrained physical nature of the microRNA-RNA-peptide nanocomplex.

The biophyiscally constrained nature of the nanocomplex is virucidal. The virucidal nature of the nanocomplex protects supercoiled DNA in the context of everything known about all levels of biological organization in all living genera.

The ATP-dependent creation of RNA, links RNA interference to what is known about fluorescence in species from microbes to humans and to the prevention of the virus-driven degradation of messenger RNA that all serious scientists know links mutations to all diseases.

What is known about biophysically constrained fluorescence has been linked to the forthcoming cure for cancer.

See: Accelerated Evolution Biotechnologies 

The ability of different peptides to inhibit autophosphorylation of EGFR is presented by the decrease of the fluorescent signal (Y axis).

Pseudoscientists and others who make money by failing to prevent unnecessary suffering and premature death, seem to hate the facts about the light-activated assembly of  of human miRISC and the nature of the microRNA-RNA-peptide nanocomplex, which biophysically constrains viral latency and helps to prevent all diseases.

The light-activated assembly of the microRNA-RNA-peptide is the link to biophysically constrained viral latency and healthy longevity. That claim reduces the number of my followers, and the number of likes rarely changes. Shadow banning? No.

See: Setting the record straight on shadow banning

If the problem that prevents the dissemination of accurate information about the prevention and/or effective treatment of all disease is not linked  to shadow banning, could it be linked to the overwhelming ignorance of experts?

See: Experts Decry Israeli Team’s Claims That They Have Found The Cure For Cancer (1/30/19)

More than 84,000 published works on microRNAs attest to the fact that these experts are trying to prevent people from learning how serious scientists are: Combating Evolution to Fight Disease

My comment from 3/7/14

Darwin probably anticipated the insemination of population genetics that led to the bastardization of his detailed observations in the “Modern Synthesis.” He politely insisted that ‘conditions of life’ be considered before natural selection.

See also: What is life when it is not protected from virus driven entropy

See also: Energy as information and constrained endogenous RNA interference



Author: James Kohl

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