Chemogenetic kinetics (3): Psychopathology

Leucine–Histidine Dipeptide Attenuates Microglial Activation and Emotional Disturbances Induced by Brain Inflammation and Repeated Social Defeat Stress 9/9/19

…daily intake of these fermented foods is negatively associated with the incidence of psychiatric diseases…

Reported as: Research discoveries suggest that leucine-histidine dipeptide improves mental health 

These research results were first reported in the online academic journal Nutrients on September 9 2019.

See for comparison: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

This invited review of nutritional epigenetics was returned without review from the online academic journal Nutrients. The preprint was published on April 10, 2014.

This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements… Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.

I published the preprint immediately after I recognized that the invitation for the invited review was an attempt to plagiarize my model and present it piece by piece in the context of published works by researchers who failed to link what was known about how the food energy-dependent Creation of the microRNA-RNA-peptide nanocomplex was linked from the pheromone-controlled physiology of reproduction in bacteria to protection from the virus-driven degradation of messenger RNA that causes all pathology.

The returned invited review was published 4 years later after I received another request for an invited review.

See: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans…. Simply put, olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.

The change in the title from This atoms to ecosystems model to This angstroms to ecosystems model, was made possible when the Zechiedrich group published Structural diversity of supercoiled DNA 10/12/15 after ridiculing biologically uninformed theorists/science idiots in this parody from 12/10/14.

See also: What is life when it is not protected from virus driven entropy 3/30/16

The ongoing scientific progress that links everything known to serious scientists about energy-dependent biophysically constrained viral latency has still not reached the much larger audience of pseudoscientists and their idiot minions who are touting different versions of mutation-driven evolution after the book link version: Mutation-Driven Evolution was published on the same day as my refutation of that nonsense: Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13

Abstract Conclusion

An environmental drive evolved from that of nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrient-dependent reproductively fit individuals across species of vertebrates.

Moving forward (from the article text)

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution.

Adaptive evolution is Darwinian. It links what organisms eat to the physiology of reproduction. Neo-Darwinian evolution links mutations to natural selection for ecologically relevant “magic traits.”

For comparison, substitution of the achiral glycine (one amino acid) in position 6 of the gonadotropin releasing hormone (GnRH) decapeptide (10 amino acids), links the food energy-dependent creation of all other peptides to the pheromone-controlled diversity of all mammals via microRNAs in milk exosomes.

Claims about how daily intake of fermented foods links the leucine–histidine dipeptide (2 amino acids) to prevention of psychiatric diseases underlie the face-saving attempts of theorists who should be credited with causing the deaths by suicide and the mass killing attributed to amino acid substitution in enzymes that link COMT Val158Met to the development of psychopathology during failed transitions from adolescence to adulthood.

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Author: James Kohl

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