Chemogenetic kinetics (1): Creation

Summary: The virus-driven theft of the sun’s anti-entropic energy, which is required for biophysically constrained cell type differentiation, causes the degradation of messenger RNA (mRNA). The degradation of mRNA links mutations to all pathology.  Fixation of energy-dependent RNA-mediated amino acid substitutions is the chemogenetic link from energy-dependent kinetics to single nucleotide polymorphisms (SNPs) and genetic variants.

See: Adaptive Properties of the Genetically Encoded Amino Acid Alphabet Are Inherited from Its Subsets 8/28/19

Reported as: Scientists find biology’s optimal ‘molecular alphabet’ may be preordained 9/10/19

The amino acids, a fundamental set of life’s building blocks, may have been adaptive throughout their evolution, suggesting a possible universal biological language.

Details on the preordination:

“There are just so many possible amino acids, and so many ways to make combinations of them, a computational approach was the only comprehensive way to address this question,” says team member Jim Cleaves of ELSI. “Efficient implementations of algorithms based on appropriate mathematical models allow us to handle even astronomically huge combinatorial spaces,” adds co-author Markus Meringer of the Deutsches Zentrum für Luft- und Raumfahrt.

The details linked God’s Creation of sunlight and water to the assembly of the microRNA-RNA-peptide nanocomplex and the functional structure of supercoiled DNA via biophysical constraints on chemogenetic kinetics and viral latency. Amino acid substitutions differentiate the cell types of all individuals in all species of all living genera.

Bernard Feringa et al., put that fact into its proper perspective on my 65th birthday in Dynamic control of chirality and self-assembly of double-stranded helicates with light 11/7/16

Simply put, like all other serious scientists before him, he placed the facts about biophysically constrained microRNA biogenesis and the genesis of all biodiversity into the context of Biblical Prophesy in: The Future of Chemistry – Schrödinger at 75: The Future of Biology (video)

Disabled were walking again, the blind were seeing again, and the death rose from the grave. 2013 was the year in which prophesy from the bible became reality. — De Correspondent dec 2013

Bokes et al. (2019) confirmed the fact that previously useless computational biology must be considered in the context of energy-dependent top-down causation and the physiology of reproduction.

See: MicroRNA based feedforward control of intrinsic gene expression noise 8/30/19

…we use the Chemical Reaction Network Theory to prove that the mRNA copy number distribution is Poissonian in the absence of spontaneous mRNA decay channel. In case of transcriptional bursts, we show that feedforward control can attenuate the super-Poissonian gene-expression noise that is due to bursting, and that the effect is more considerable at the protein than at the mRNA level. Our results indicate that the strong coupling between mRNA and microRNA in the sense of burst stoichiometry and also of timing of production events renders the microRNA based feedforward motif an effective mechanism for the control of gene expression noise.

Differences in terms used to obfuscate the facts about feedback loops should have been eliminated via publication of:

Feedback loops link odor and pheromone signaling with reproduction (2005)

It appears that GnRH neurons integrate a variety of information about the internal state of the animal and its external environment. At least 10,000 neurons in 26 different brain areas appear to transmit signals directly to GnRH neurons. Among these are areas involved in odor and pheromone processing, sexual behavior, arousal, reward, and other functions. This suggests that GnRH neurons are poised to modulate reproductive physiology and behavior in accordance with the overall state of the animal.

These studies also indicate that GnRH neurons are likely to influence numerous brain functions. They appear to transmit signals to as many as 30,000 or more neurons in 34 brain areas, consistent with previous studies showing GnRH+ fibers and GnRH receptors in multiple brain regions (Badr and Pelletier, 1987; Jennes et al., 1988; Jennes et al., 1997). BL+ neurons likely to receive synaptic input from GnRH neurons were seen in areas associated with numerous different functions, including odor and pheromone processing, sexual behavior, appetite, defensive behavior, motor programs, and the relay of information to higher cortical areas. These results may reflect a strategy wherein GnRH neurons can modify diverse functions in order to coordinate the internal state of the animal and its behavior with reproduction in order to optimize reproductive success.

In the context of microRNA based feedforward loops and feedback loops there is no difference between non-classical light and classical light. Use of computational biology to invent differences in what some people call non-classical light and what intelligent people call sunlight (i.e., classical light) are irrelevant.

Clearly, the light-activated energy-dependent fixation of achiral glycine in position 6 of the GnRH decapeptide should have eliminated the pseudoscientific nonsense touted about the evolution of amino acids in:

A universal trend of amino acid gain and loss in protein evolution (2005)

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

All serious scientists know that even if the compositions could have evolved, fixation does not occur outside the Creation of sunlight, ATP, microRNA biogenesis, the Creation of RNA, which links the patent for naturally occurring RNA interference to the end of neo-Darwinian theories and Big Bang cosmology.

Simply put, energy did not emerge from nothing, and no species has ever evolved into another species.

Author: James Kohl

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