CDC vs WHO (2): Adaptive regulatory variation

Summary: In their presentation from  the 2018 meeting of the American Society for Human Genetics, the Broad Institute, Jackson Laboratory, the Harvard University Department of Organismic and Evolutionary Biology, and the researchers from the Harvard Medical School summarily refuted Theistic evolution/neo-Darwinism/mutation-driven evolution.

A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

 …plants alter microRNA (miRNA) biogenesis in response to light transition.

Light-activated microRNA  production, which is called microRNA (miRNA) biogenesis, has since been linked from plants to miRNA-Mediated Interactions in and between Plants and Insects

…in plant-insect interactions, both plants and insects use miRNAs to regulate their biological processes, as well as co-opting each others’ miRNA systems. In this review article, we discuss the current paradigms of miRNA-mediated cellular regulation and provide examples of plant-insect interactions that utilize this regulation.

Senior author Jerome Hui was featured in this report from 2015: miRNA sequences have been used to sort out phylogenetic relationships.

Non-coding RNAs such as microRNAs (miRNA) are now recognized as important regulators of gene expression.

See also 7 other publications co-authored by Hui, whose expertise links more than 79,000 other reports from facts about microRNA biogenesis to the role that microRNA flanking sequences play in biophysically constrained viral latency, which prevents the degradation of messenger RNA that has linked mutations to all pathology.

Researchers from China and from other countries have joined scientific Creationists from South Korea who continue to refute all theories proposed by biologically uninformed science idiots. See:

Desires of Microscopic Shrimp Illuminate Evolutionary Theory December 27, 2014

I’ve always been interested in speciation and how species form, but this is a whole different mechanism, that light can influence speciation,” Ellis says. “I thought it was just fabulous.

The creation of sunlight and light-activated microRNA biogenesis are the only obvious links to biophysically constrained viral latency and the prevention of all diseases in all livng genera.

See also: Human Exosomes: An Ideal Vehicle for Delivery of Therapeutic RNAs to Cells and Organs

It can either be used to silence pathological genes using RNA interference (RNAi) or express therapeutic proteins by delivering mRNA to cells.

The biophysically constrained creation of ATP and RNA links naturally occurring microRNA biogenesis to its potential for treating various diseases via RNAi.

That is why George Church et al., patented the naturally occurring process of RNA interference (1. RNA-guided human genome engineering) with hopes of delivering a “billion dollar baby” to those who could afford the therapy, which will be required after illegal immigrants unleash the power of the viruses they carry to decimate populations of humans who have not yet adapted to the viruses of large numbers of people from other countries. See: 2. Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy

  1. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).
  2. RNAi has targeted exogenous genes in models of viral infection

Historical perspective:

The American Indians were decimated by the smallpox virus. The Democrat’s plan to help corporate America continue to make billions of dollars from the unnecessary suffering and premature death of millions may still succeed if the horde of illegal immigrants cannot be stopped by the Trump Administration.

See also: The Curious Case of the Spanish Flu

It is often claimed that the exceptional severity of the Spanish flu, one of the most deadly events in recorded human history, is an unsolved mystery. However, even detailed aspects such as its W-shaped mortality curve are well explained by Paul Ewald’s theory of the evolution of virulence. Understanding the causes of the Spanish flu will help to prevent future epidemics.

Frans Roes asks why the reasons for natural selection have often been left out of analyses. He hopes it will not “…take another century to arrive at generally accepted conclusions about the evolution of the Spanish flu.”

He is in luck. The hecatombic evolution of virulence has been linked to all diseases. See:  Virus-mediated archaeal hecatomb in the deep seafloor. For contrast, food energy-dependent feedback loops have linked pheromone-controlled polycombic ecological adaptations to all healthy longevity via the creation of amino acids and fixation of substitutions that stabilize the organized genome of species from microbes to humans.

See: From Fertilization to Adult Sexual Behavior

Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

The feedback loops link food odor and pheromones from alternative splicings of pre-mRNAs , which are now called microRNAs, to biophysically constrained viral latency. Viral latency is linked to the development of mature phenotypes, which are required for the long-term success of species-specific, sex-specific, and tissue-specific adaptive regulatory variation.

See: Feedback loops link odor and pheromone signaling with reproduction (2005)

The feedback loops link natural selection for energy-dependent codon optimality from Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition to the amino acid composition of all cell types via the stability of messenger RNA. That fact has been manifested in fixation of achiral glycine in position 6 of the gonadotropin releasing hormone (GnRH) decapeptide and the EDAR V370A allele in the context of the mouse-to-human model of adaptive regulatory variation.

See also: Identification and characterization of adaptive regulatory variation in diverse human populations. 10/18/18

…natural selection acts on phenotypes affecting long-term outcomes of reproduction and survival.

…we identify tissue-specific enrichments for putative adaptive regulatory alleles…

Natural selection acts on phenotypes that biophysically constrain viral latency via adaptive regulatory alleles. The energy-dependent creation of the regulatory alleles come before natural selection. In their presentation from  the 2018 meeting of the American Society for Human Genetics, the Broad Institute, Jackson Laboratory, the Harvard University Department of Organismic and Evolutionary Biology, and the researchers from the Harvard Medical School summarily refuted Theistic evolution/neo-Darwinism/mutation-driven evolution.

See also: Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements

Reported as: Breastfeeding protects infants from antibiotic-resistant bacteria

See also: Genome-Wide Mapping of Uncapped and Cleaved Transcripts Reveals a Role for the Nuclear mRNA Cap-Binding Complex in Co-translational RNA Decay in Arabidopsis

Reported with this spurious claim: Study identifies new mechanism of RNA degradation in plants

The virus-driven degradation of RNA in plants has been linked by every intelligent scientist to the light-activated molecular mechanisms of microRNA biosynthesis, which have been linked from biophysically constrained viral latency to all biodiversity via food energy and the pheromone-controlled physiology of reproduction.

See what’s coming during the week of the November mid-term elections:

SFN abstracts online

 The microRNA and mRNA profile of Müller glia after light damage

…glial miRNAs might be important for the maintenance of the physiological function and might also play a role in degenerative diseases.

Role of a 3’utr polymorphism (rs2304297) in the human alpha 6 nicotinic receptor subunit gene in adolescent substance use

…our study aims to understand the genetic, environmental, and neurobiological mechanisms mediating the effects of the Chrna6C123G genetic variant on adolescent substance use. Our findings could have a important impact in the scientific and public health communities which may contribute to the development of improved prevention and intervention strategies for addiction.

miRNAs shuttled by exosomes derived from mesenchymal stem cells move spinal cord astrocytes isolated from SOD1G93Amice at the late phase of disease from a neurotoxic to a neuroprotective phenotype

…exosomes and their miRNAs ameliorate the inflammatory state and promote a shift of astrocytes to a neuroprotective phenotype. These data are promising for translational pre-clinical trials in SOD1G93A mice.

Roles of exosomal microRNAs derived from inflammatory macrophages in Alzheimer’s disease

…exosomes derived from LPS-stimulated macrophages contain increased levels of several miRNAs including miR-146a, which can induce LPS tolerance. Our data suggest that exosomes derived from inflammatory macrophages can modulate microglial responses to LPS in …vitro.

The Democrats lost control over the release of facts that refute neo-Darwinian pseudoscientific nonsense via what is known about energy-dependent epigenetic effects on viral latency.
The virus-driven degradation of messenger RNA causes the loss of control of gene activity, which has been linked to all diseases. Effective treatments are already available but they do not provide the profits needed by Democrats to continue to tout their deadly agenda.
This FB post will not go viral and neurodegenerative diseases, such as Alzheimer’s, will continue to be caused by the ignorance of Democrats who have not linked the virus-driven degradation of messenger RNA from mutations to all diseases.

Author: James Kohl

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