Category: Variations
Do not call me Ishmael (4)
Summary: This interaction links the food energy-dependent pheromone-controlled creation of enzymes and receptors to biophysically constrained viral latency via the amino acid substitutions that differentiate…
Plant microRNAs regulate across-kingdom gene expression (2)
Multiple layers of cryptic genetic variation underlie a yeast complex trait 1/4/19 Oligos were 90 bases long with homology to either FLO8 or SFL1, with…
Sex-specific microRNA-mediated cancer treatment
Glioblastoma Pathway Signatures, Treatment Responses Differ Between Male, Female Patients …greater precision in the stratification of patients with GBM may be achieved through sex-specific molecular…
Hide and seek with science facts (7)
See: Hide and seek with facts (6) Now that Alexandria Ocasio-Cortez has been elected to represent New York’s 14th Congressional District, her 2007 presentation on nematodes…
Hide and seek with science facts (6)
Bernard Feringa: The Future of Chemistry – Schrödinger at 75: The Future of Biology (video) Levulan Kerastick and Blu-U link light-activated microRNA biogenesis in plants…
Bottom-up biology (revisited)
See first: Bottom up biology Summary: Serious scientists have linked UV light-activated gene expression and the cascade of base editing, microRNA editing and RNA editing…
10,000 reasons to believe in biophysical constraints (2)
If you are going to #SFN2018 #SFN, you may need an update on what is known to all serious scientists. For example, compared to theorists,…
Creation of an enzyme that kills theories (3)
Summary: Yesterday, the pseudoscientific nonsense touted by biologically uninformed population geneticists was placed into the context of the #ASHG18 Presidential address. Previously: Light-activated microRNA biogenesis…
Paired symbolism and suicide prevention (2)
Fatty-acid derivative acts as a sea lamprey migratory pheromone Reported as: Pinpointing a molecule for sea lamprey control …the pheromone bridges two distinct life stages…
Paired symbolism and suicide prevention (3)
Assembling yeast chromosomes like Legos has a serious goal: safe lab-made creatures Boeke and his team had created yeast cells whose 16 chromosomes had been…
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.