Category: Pheromones
MicroRNA biogenesis vs Big Bang abiogenesis
Could the Big Bang be Wrong? …he came up with a complicated oscillating-universe model… The energy-dependent oscillations link light-activated carbon fixation from microRNA biogenesis to…
Ecological Adaptations: From Angstroms to Ecosystems (2)
From the time I published my review of biophysically constrained nutritional epigenetics, which refuted the neo-Darwinian nonsense about mutation-driven evolution, 2834 more publications have mentioned…
Kohl and Francoeur at 25 (8)
Epigenetic Regulations in Neuropsychiatric Disorders (4/4/19) This article is part of the Research Topic: Genetics and Epigenetics of Psychiatric Diseases For a historical perspective on…
Olfaction and microRNA signaling constrain longevity (4)
See: RNAi from Petunias to Worms (2006) Small RNAs can also be used to turn off large portions of the genome near centromeres via the…
The tipping point (revisited): 85,000 publications (3)
Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) The synthesis of RNA in…
The tipping point (revisited): 85,000 publications
microRNA Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death (1/25/19) …various activators and modulators of NR4A2 have…
Epic failure of the FDA: Gottlieb resigns (2)
Epic failure of the FDA: Gottlieb resigns (1) We didn’t know it was possible for cells to survive crisis; we didn’t know autophagy is involved…
DS Wilson’s view of biophysically constrained life (3)
A Different Kind of Theory of Everything (2/19/19) 1) In 1964, during a lecture at Cornell University, the physicist Richard Feynman articulated a profound mystery…
Blood music orchestrates human life (3)
Potential Excessive Testing at Scale: Biomarkers, Genomics, and Machine LearningPotential Excessive Testing at Scale: Biomarkers, Genomics, and Machine LearningPotential Excessive Testing at Scale: Biomarkers, Genomics,…
Light-activated carbon fixation (2)
Raman‐activated cell sorting and metagenomic sequencing revealing carbon‐fixing bacteria in the ocean 5/4/18 …anaplerotic CO2 fixation in PR containing Dokdonia sp. MED134 provided up to…
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.