Category: Pharmacogenomics
2020 National Vaccine Plan (1)
All polymaths probably know that the claims from Unified rational protein engineering with sequence-based deep representation learning 10/21/19 attest to facts about why vaccines are…
Nutrient-dependent Pheromone-controlled cures (2)
See: Nutrient-dependent Pheromone-controlled cures (1) My summary: They linked one base pair and one amino acid in a light-assembled microRNA-RNA-peptide nanocomplex to protection from nutrient…
The tipping point (revisited): 89K (3)
How Precision Medicine Is Changing Cancer Treatment (6/24/19) The most basic explanation for the complex process of cancer is that a genetic mutation either flips…
Kohl and Francoeur at 25 (7)
MicroRNA Items: 1 to 20 of 84999 Feed-forward information and zero-lag synchronization in the sensory thalamocortical circuit are modulated during stimulus perception (3/25/19) …directional and…
Liberals and theorists cause gun violence (2)
Psychiatry’s Incurable Hubris Modern medicine pivots on the promise that portraying human suffering as biological disease will lead to insight and cures. Inescapably, this enterprise…
Liberals and theorists cause gun violence (1)
Big data study identifies drugs that increase risk of psychosis in youth with ADHD A child treated with amphetamine is twice as likely as a…
Hide and seek with science facts (7)
See: Hide and seek with facts (6) Now that Alexandria Ocasio-Cortez has been elected to represent New York’s 14th Congressional District, her 2007 presentation on nematodes…
MicroRNA-mediated feedback loops (3)
DNA Methylation: Timekeeper of Biological Age Cellular senescence, telomere shortening, and changes in gene expression have been well documented to contribute to the aging process….
Amino acid sequences: humans, chimpanzees, and gorillas
behavior, development, morphology, phenotypic plasticity A nucleus-like compartment shields bacteriophage DNA from CRISPR-Cas and restriction nucleases All viruses require strategies to inhibit or evade the…
The tipping point (revisited): 75,000 publications (2)
A Sweeping Role for MicroRNAs in Neuronal Disease, Vascular Disorders, and as Prognostic Indicators Open access download available: Conclusion: These novel studies form an interesting…
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.