Category: MicroRNA biogenesis
Epic failure of the FDA: Gottlieb resigns (3)
From Epic failure of the FDA: Gottlieb resigns (2) I reiterate: The link from the anti-entropic virucidal energy of sunlight to naturally occurring RNA interference…
Kohl and Francoeur at 25 (7)
MicroRNA Items: 1 to 20 of 84999 Feed-forward information and zero-lag synchronization in the sensory thalamocortical circuit are modulated during stimulus perception (3/25/19) …directional and…
Kohl and Francoeur at 25 (5)
A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation …plants alter microRNA (miRNA) biogenesis…
The tipping point (revisited): 85,000 publications (2)
Adaptive multi-view multi-label learning for identifying disease-associated candidate miRNAs (4/1/19) Increasing evidence has indicated that microRNAs (miRNAs) play vital roles in various pathological processes and…
Epic failure of the FDA: Gottlieb resigns (2)
Epic failure of the FDA: Gottlieb resigns (1) We didn’t know it was possible for cells to survive crisis; we didn’t know autophagy is involved…
microRNAs combat diseases
The roles of microRNAs in epigenetic regulation …we focus on the reciprocal interconnection of miRNAs in epigenetic regulation, with the aim of offering new insights…
DS Wilson’s view of biophysically constrained life (3)
A Different Kind of Theory of Everything (2/19/19) 1) In 1964, during a lecture at Cornell University, the physicist Richard Feynman articulated a profound mystery…
RNA processing and disease 2019 (1)
Steve Mount Ongenetics, (Univ. of Maryland. Interested in gene structure and function, especially pre-mRNA splicing) wrote: At #BPIRPD2019 Michael Sattler A great story, many vignettes…
Ecological adaptation vs neo-Darwinian nonsense (3)
See for comparison to Kohl’s Laws of Biology / Darwin’s conditions of life, which require links from the creation of energy to light-activated changes in…
Non-random vs random selection for receptor clonotypes
High frequency of shared clonotypes in human B cell receptor repertoires Reported as: Decoding the human immune system (2/13/19) The receptors randomly select and join…
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.