Category: MicroRNA biogenesis
Non-random vs random selection for receptor clonotypes
High frequency of shared clonotypes in human B cell receptor repertoires Reported as: Decoding the human immune system (2/13/19) The receptors randomly select and join…
Darwin Day 2019 (3) #darwinday2019
Start over on #darwinday2019 with Thomas Hunt’s (1855) On the Influence of the Human Instinct in the Prevention and Cure of Disease, Chiefly in Reference…
Blood music orchestrates human life (1)
Summary: It is clear that light-activated oxygen-dependent microRNA biogenesis is the key to the ‘music of life’ via the physiology of reproduction, which links sympatric…
Biophysically constrained fast adaptation (3)
Excerpt: “One fascinating aspect of innate self-adjusting mechanisms appears to be a programmed “strategy” for adaptation that corresponds in function to programs that human engineers…
Biophysically constrained fast adaptations (2)
Carl Zimmer made a podcast. There are eight episodes of “What Is Life?” He asks people who he thinks are experts about the big question….
Biophysically constrained fast adaptations (1)
During the month of January (2018), 2831 people learned from my profile about the domains RNA-mediated.com and Autophagy.pro Some of them learned from more than…
10,000 reasons to believe in biophysical constraints (revisited)
On January 29, 2019 to January 30, 2019, my Tweets made more than 10,000 impressions (total 12,200). I followed-up on the claim about A cure…
Light-activated constrained biodiversity
Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism (2015) A single set of light-activated reactions was linked to the production of…
Light-activated carbon fixation (1)
See: Olfaction Warps Visual Time Perception The sense of smell in bacteria has been linked from the physiology of pheromone-controlled reproduction by feedback loops that…
Facts about microRNAs embarrass US researchers (1)
Double-edged effects of noncoding RNAs in responses to environmental genotoxic insults: Perspectives with regards to molecule-ecology network Molecular-ecological network (MEN) insights into the underlying mechanisms regarding…
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.