Category: Autophagy
The tipping point (revisited): 87K (2)
Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions. The antigenic changes have been linked to…
The tipping point (revisited): 87K (1)
A multicellular way of life for a multipartite virus (3/12/19) …the viral genome is not recapitulated in a single virus particle but in the viral…
Ecological Adaptations: From Angstroms to Ecosystems (2)
From the time I published my review of biophysically constrained nutritional epigenetics, which refuted the neo-Darwinian nonsense about mutation-driven evolution, 2834 more publications have mentioned…
Olfaction and microRNA signaling constrain longevity (2)
Olfaction and microRNA signaling constrain longevity (1) 3/30/16 The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in…
Olfaction and microRNA signaling constrain longevity (1)
Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics…
Kohl and Francoeur at 25 (6)
Excerpt: Natural selection for energy-dependent codon optimality links what animals like to eat to biophysically constrained viral latency vira the physiology of their pheromone-controlled reproduction…
Epic failure of the FDA: Gottlieb resigns (2)
Epic failure of the FDA: Gottlieb resigns (1) We didn’t know it was possible for cells to survive crisis; we didn’t know autophagy is involved…
Epic failure of the FDA: Gottlieb resigns (1)
Autophagic cell death restricts chromosomal instability during replicative crisis 1/22/19 Our data suggest that autophagy is an integral component of the tumour suppressive crisis mechanism…
Biophysical constraints on RNA synthesis (1)
Includes: Constraints on amino acid substitutions in peptides Constraints on nanocomplexes Constraints on systems complexity Summary: The role that energy-dependent changes in the microRNA/messenger RNA…
Preprints obfuscate facts (2)
See: Preprints obfuscate facts (1) See the preprint: Genetic dissection of assortative mating behavior 3/14/18 See also: PLOSBiology 2/7/19 Ecologically relevant mating cues (sometimes known…
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.