Posted in Adaptations Alternative Splicings Diseases & Disorders Ecology MicroRNA biogenesis RNA interference

The eternal significance of microRNA biogenesis (1)

In the first two decades of the twenty-first century, serious scientists forced pseudoscientists and drug developers to make more foolish claims. The additional claims were…

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Posted in Adaptations Alternative Splicings Diseases & Disorders Ecology Subatomic

The tipping point (revisited): Big Data (3)

Food energy-dependent alternative splicings of pre-messenger RNAs, which are also called microRNAs, link the pheromone-controlled physiology of reproduction in species from microbes to humans to…

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Posted in Adaptations Alternative Splicings base editing biophotonics Diseases & Disorders Ecology

The tipping point (revisited): Big Data (1)

Technological advances in omics link the measurement of fluorescence in supercoiled DNA from light-activated microRNA biogenesis to energy-dependent signaling pathways and dynamic changes in angstroms…

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Posted in Adaptations Alternative Splicings base editing Cytosis Diseases & Disorders Ecology Light Energy Model Organisms RNA interference Subatomic

The tipping point (revisited): Genetics & Genomics 2019

High-Amylose Maize, Potato, and Butyrylated Starch Modulate Large Intestinal Fermentation, Microbial Composition, and Oncogenic miRNA Expression in Rats Fed A High-Protein Meat Diet (4/30/19) All…

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Posted in Adaptations Alternative Splicings base editing biophotonics Cytosis Diseases & Disorders Ecology Subatomic

The tipping point (revisited): SETD2

“Darwin had a huge data set and no mechanism—where would he publish today? This is a problem!” — Arturo Casadevall Yesterday, it became obvious that Darwin…

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Posted in Adaptations Alternative Splicings base editing biophotonics Diseases & Disorders Ecology MicroRNA MicroRNA biogenesis microRNA editing RNA interference

Epic failure of the FDA: Gottlieb resigns (3)

From Epic failure of the FDA: Gottlieb resigns (2) I reiterate: The link from the anti-entropic virucidal energy of sunlight to naturally occurring RNA interference…

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Posted in Adaptations Alternative Splicings base editing Cytosis Diseases & Disorders Ecology Light Energy Subatomic

Olfaction and microRNA signaling constrain longevity (3)

Genetic compensation triggered by mutant mRNA degradation 4/3/19 Transcriptome analysis in alleles displaying mutant mRNA decay reveals the upregulation of a substantial proportion of the…

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Posted in Adaptations Alternative Splicings Autophagy base editing Cytosis Diseases & Disorders Ecology Light Energy microRNA editing Physics RNA editing RNA interference

Kohl and Francoeur at 25 (6)

Excerpt: Natural selection for energy-dependent codon optimality links what animals like to eat to biophysically constrained viral latency vira the physiology of their pheromone-controlled reproduction…

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Posted in Adaptations Alternative Splicings Diseases & Disorders Ecology Human Pheromones Model Organisms Pheromones RNA editing

The tipping point (revisited): 85,000 publications (3)

Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) The synthesis of RNA in…

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Posted in Alternative Splicings base editing Diseases & Disorders Human Brain Pharmacogenomics

Liberals and theorists cause gun violence (1)

Big data study identifies drugs that increase risk of psychosis in youth with ADHD A child treated with amphetamine is twice as likely as a…

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