Category: Alternative Splicings
Biologos bastardized it all again (3)
Summary: The trapped nutrients biophysically constrain viral latency via the light-activated fixation of carbon in all cell types of all living genera. That is how…
Catch 22: Democrats lose it all (2)
Democrats lost their grip on reality in the context of their greed and attempts to support the money-making pseudoscientists who have failed to make scientific…
Emergence of a coherent model
Transcription drives DNA replication initiation and termination in human cells …although origins have been observed via several independent techniques to be enriched close to transcribed…
Copying Nature’s Design Process (1)
“What I do is copy nature’s design process.” October 3, 2013 (video 5:41 minutes) For 2018 Nobel Chemistry Prize Laureate Frances H. Arnold, evolution is…
The tipping point (revisited): 78,000 publications (1)
9/10/18 The tipping point (revisited): 77,000 publications (3) See: MicroRNA (I’m reporting in advance that in less than one month more than 1000 publications have…
Energy-dependent thymic involution vs evolution (1)
Historical perspective: See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) The synthesis…
Theorists: The biggest threat to microRNA-mediated security
Summary: Kevin J. Mitchell is a biologically uninformed theorist. Food energy-dependent microRNA-mediated protein crowding in the cell types of human blood links the hemoglobin S…
microRNA targeting efficacy refutes ridiculous theories
The biochemical basis of microRNA targeting efficacy Hold on, this is waiting to be approved by BioRxiv. This highly significant somewhat cloaked advancement of a…
Creation vs evolution of ribonucleotide removal strategies (1)
Summary: See: The biochemical basis of microRNA targeting efficacy and Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining science. The preprint and…
Predicting the CRISPR Cas9 Market Collapse
Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo Knowing that nucleosomes interfere directly with Cas9 cleavage, but not with ZFN cleavage, is useful information. It…
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.