Category: Alternative Splicings
Epic failure of the FDA: Gottlieb resigns (3)
From Epic failure of the FDA: Gottlieb resigns (2) I reiterate: The link from the anti-entropic virucidal energy of sunlight to naturally occurring RNA interference…
Olfaction and microRNA signaling constrain longevity (3)
Genetic compensation triggered by mutant mRNA degradation 4/3/19 Transcriptome analysis in alleles displaying mutant mRNA decay reveals the upregulation of a substantial proportion of the…
Kohl and Francoeur at 25 (6)
Excerpt: Natural selection for energy-dependent codon optimality links what animals like to eat to biophysically constrained viral latency vira the physiology of their pheromone-controlled reproduction…
The tipping point (revisited): 85,000 publications (3)
Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) The synthesis of RNA in…
Liberals and theorists cause gun violence (1)
Big data study identifies drugs that increase risk of psychosis in youth with ADHD A child treated with amphetamine is twice as likely as a…
RNA processing and disease 2019 (1)
Steve Mount Ongenetics, (Univ. of Maryland. Interested in gene structure and function, especially pre-mRNA splicing) wrote: At #BPIRPD2019 Michael Sattler A great story, many vignettes…
Ecological adaptation vs neo-Darwinian nonsense (2)
Understanding quantum physics in the context of the light-activated assembly of the nucleic acid-microRNA-peptide nanocomplex (L-ANAMPNC or L-ANC, for short) is essential to the understanding…
Non-random vs random selection for receptor clonotypes
High frequency of shared clonotypes in human B cell receptor repertoires Reported as: Decoding the human immune system (2/13/19) The receptors randomly select and join…
Blood music orchestrates human life (2)
From: Blood music orchestrates human life (1) The assessment of phylogenetic relationships that link the creation of sunlight and water to oxygen and microRNA biogenesis…
Do not call me Ishmael (4)
Summary: This interaction links the food energy-dependent pheromone-controlled creation of enzymes and receptors to biophysically constrained viral latency via the amino acid substitutions that differentiate…
James V. Kohl detailedl how quantized energy-dependent microRNA biogenesis links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency and healthy longevity. Links from what organisms eat to the enzyme-dependent metabolism of food also link metabolic networks to microRNA-mediated genetic networks in the context of RNA interference. Drug therapies alter RNA interference by altering cell type differentiation in all cells of all individuals of all species. For comparison, during the past 26 years, Kohl has detailed how the chemistry of protein folding is biophysically constrained at every level of biological organization by conserved molecular mechanisms.