Bruce S. McEwen’s legacy: sympatric speciation (2)

The ever increasing number of publications that link microRNA-mediated top down causation to prevention of virus-driven pathology attests to the facts from Biology could be so much more 11/22/19

…all that hard-earned expertise can get in the way. After all, nature isn’t neatly divided along disciplinary lines, so understanding it requires an integrated way of thinking. Put it this way: There’s a lot you can’t see when your eyes are glued to the microscope.

It’s a problem that Bruce S. McEwen often thinks about. A neuroendocrinology specialist and self-described nerd, he is wary of the fact that the more you become an expert on something, the more isolated you become.

Most specialists with their hard-earned expertise did not learn how to integrate what is known about the Creation of sunlight and water into a model of the oxygen-dependent prevention of DNA damage caused by nutrient-stress and social stress. That is why they failed to link stress to virus-driven physical and/or behavioral pathology.

See: Effects of chronic silencing of relaxin-3 production in nucleus incertus neurons on food intake, body weight, anxiety-like behaviour and limbic brain activity in female rats 1/3/20

Who are the experts who linked changes in behavior to facts about energy-dependent microRNA-mediated biophysical constraints?

See: Mitochondrial TCA cycle metabolites control physiology and disease 1/3/20

For comparison, see:  Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Pseudoscientists do not want intelligent people to know that the ATP-dependent creation of RNA biophysically constrains viral latency and all pathology. The pseudoscientists prefer to obfuscate epigenetic cause and effect with claims about mutation-driven evolution and/or titles, such as this one.

A human minisatellite hosts an alternative transcription start site for NPRL3 driving its expression in a repeat number‐dependent manner 1/3/20

The pseudoscientists know that most people will not look at the complexity of top-down energy-dependent biophysically constrained Creation of cell type differences in the context of articles like this one:

microRNA-181 serves as a dual-role regulator in the development of human cancers 12/30/19

MicroRNAs (miRNAs) as the regulatory short noncoding RNAs are involved in a wide array of cellular and molecular processes.

…act as oncomirs or tumor suppressors …involved in cell proliferation, apoptosis, autophagy, angiogenesis…exert their regulatory effects through modulating multiple signaling pathways…

All the signalling pathways are also linked to drug resistance, which is a Big Pharma nightmare. Drug development virtually stalled when facts about naturally occurring light-activated carbon fixation were linked to biophysically constrained RNA interference in this patent for the prevention of all virus-driven pathology.

See: RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

See also:  Specific Inhibition of Viral MicroRNAs by Carbon Dots-Mediated Delivery of Locked Nucleic Acids for Therapy of Virus-Induced Cancer 1/2/20

miR‑217 and miR‑543 downregulation mitigates inflammatory response and myocardial injury in children with viral myocarditis by regulating the SIRT1/AMPK/NF‑κB signaling pathway 12/27/19

Pseudoscientists prefer to place their claims about viruses into the context of inferences in articles like this one.

Inferring the Disease-Associated miRNAs Based on Network Representation Learning and Convolutional Neural Networks 7/25/19

Serious scientists reject the inferences of pseudoscientists and continue to contribute experimental evidence of biophysically constrained cause and effect.

See for instance: Abnormal expression of rno_circRNA_014900 and rno_circRNA_005442 induced by ketamine in the rat hippocampus. 1/2/20

miR-335 modulates Numb alternative splicing via targeting RBM10 in endometrial cancer 1/2/20

hnRNPA2B1 inhibits the exosomal export of miR-503 in endothelial cells 1/2/20

MicroRNA-9119 regulates cell viability of granulosa cells in polycystic ovarian syndrome via mediating Dicer expression 1/1/20

MiR-490-5p functions as tumor suppressor in childhood neuroblastoma by targeting MYEOV 1/1/20

Role of microRNAs in antiviral responses to dengue infection 1/3/20

…miRNAs that could modulate immunopathogenesis are discussed. Major hurdles lie in the development of chemical modifications and delivery systems for in vivo delivery. Nevertheless, advancement in miRNA formulations and delivery systems hold great promise for the therapeutic potential of miRNA-based therapy…

I have repeatedly mentioned that the energy-dependent microRNA-mediated cure for all cancers was patented on 12/25/18. See: Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest and see their Proof of concept

The proof of concept links their creation of energy-dependent peptides to prevention of cancers caused by the virus-driven degradation of messenger RNA, which links the creation of toxic peptides to all pathology.

See also: Gene Ontology: A Resource for Analysis and Interpretation of Alzheimer’s Disease Data 12/20/19

Role of microRNAs in remodeling the tumor microenvironment (Review) 12/24/19

ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells 12/20/19

miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8 12/23/19

miR‑146a improves hepatic lipid and glucose metabolism by targeting MED1 12/27/19

miR‑139‑5p affects cell proliferation, migration and adipogenesis by targeting insulin‑like growth factor 1 receptor in hemangioma stem cells 12/17/19

eIF4E‑related miR‑320a and miR‑340‑5p inhibit endometrial carcinoma cell metastatic capability by preventing TGF‑β1‑induced epithelial‑mesenchymal transition 12/16/19

Identification and validation of mRNA 3’untranslated regions of DNMT3B and TET3 as novel competing endogenous RNAs of the tumor suppressor PTEN 12/20/19

miR‑20b promotes growth of non‑small cell lung cancer through a positive feedback loop of the Wnt/β‑catenin signaling pathway 12/13/19

Noncoding RNAs in Critical Limb Ischemia 1/2/20

The only hope that serious scientists may prevail against the pseudoscientific nonsense, which obfuscates cause and effect, comes from those who know how to link what organisms eat the the stability of organized genomes across kingdoms.

See for example: Curcumin rescues breast cells from epithelial‑mesenchymal transition and invasion induced by anti‑miR‑34a 12/13/19

See also: Precision Medicine Approaches to Prevent Gastric Cancer 1/6/20

Inhibition of miR-34a-5p protected myocardial ischemia reperfusion injury-induced apoptosis and reactive oxygen species accumulation through regulation of Notch Receptor 1 signaling 9/30/19

MicroRNAs in tumor immunity: functional regulation in tumor-associated macrophages 12/21/19

A novel miRNA located in the GATA4 gene regulates the expression of IGF-1R and AKT1/2 genes and controls cell proliferation 1/3/20

Severe obstructive sleep apnea is associated with circulating microRNAs related to heart failure, myocardial ischemia, and cancer proliferation 1/3/20

Research progress on the interactions between long non-coding RNAs and microRNAs in human cancer 12/4/19

Insight into the effects of microRNA-23a-3p on pancreatic cancer and its underlying molecular mechanism 11/19/19

Overexpression of microRNA-203 can downregulate survivin and function as a potential therapeutic target in papillary thyroid cancer 11/13/19

The role of deubiquitinating enzymes in gastric cancer 11/7/19

Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression 11/13/19 [Korea]

If it is not yet obvious to you that all serious scientists will continue to refute the nonsense touted by neo-Darwinian theorists and Big Bang cosmologists, you need only search for more indexed published works that mention the term “microRNA” for comparison to those that ignore more than 96,000 already published works linked to sympatric speciation across kingdoms via the Creation of sunlight, water, and oxidative phosphorylation.

See for example: Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits 1/3/20

The epic failure of genome-wide association studies (GWAS) to unravel facts about energy-dependent gene expression, microRNA-mediated proteomics, and biophysically constrained metabolomics has failed to link numerous pathophysiological pathways to complex disorders and generated only many more useless hypotheses that cannot be linked to the functional structure of supercoiled DNA via oxidative phosphorylation, which protects organized genomes from virus-driven pathology.

Author: James Kohl

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