Potential Excessive Testing at Scale: Biomarkers, Genomics, and Machine LearningPotential Excessive Testing at Scale: Biomarkers, Genomics, and Machine LearningPotential Excessive Testing at Scale: Biomarkers, Genomics, and Machine Learning 1/8/19
One of two co-authors of this “viewpoint,” Kenneth D. Mandl wrote (with my emphasis):
Biomarkup—when biomarkers are promoted and sometimes even designed for economic gain. @arjunmanrai and I expect it to be a hallmark of genomic and AI-driven medicine. @JAMA_current http://bit.ly/2SEAB2o
Dr. Michael Joyner wrote (with my emphasis):
This is such an important paper – the incidentalome on steroids @zakkohane & what do your enthusiast colleagues @broad and MGH say? @cecilejanssens @VPrasadMDMPH @ACasadevall1 @sandrogalea @jflier
Previously, Joyner claimed that Precision medicine’s rosy predictions haven’t come true. We need fewer promises and more debate
Endless debate is common among theorists and biologically uninformed pseudoscientists. I was surprised to see Joyner claim we need more debate and then comment on the incidentalome. I had never heard a serious scientist mention the incidentalome in any context whatsoever.
Does the ‘incidentalome’ link the National Microbiome Initiative to the Precision Medicine Initiative and the cure for all virus-driven pathology such as cancer (i.e., the light-activated assembly of the peptide nucleic acid-microRNA nanocomplex)?
For comparison, the light-activated assembly of the peptide nucleic acid-microRNA nanocomplex has been linked to: Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
The link was reported as: Blood cells could hold master clock behind aging (2/7/19)
The study showed blood cells retain epigenetic patterns in DNA methylation—chemical groups attached to DNA—that can be used to calculate their age.
…Matsuyama’s team is working to understand why epigenetic age differences exist in cancer cells, and how they could be overcome. “It may be by turning on or off certain genes within the cells, we can reset the clock.”
Recent studies show the DNA age of human cells can be used as a biomarker to predict the risk of age-associated diseases, such Alzheimer’s disease, cardiovascular disease, and others. Last year, Horvath and Matsuyama helped publish an article reporting that DNA age is significantly accelerated in Progeria patients who suffer from premature aging. Matsuyama and his colleagues now have several studies underway to uncover the mechanism of age-dependent DNA methylation, and to understand how factors such as diet, exercise, and oxygen levels influence epigenetic clocks.
What role does the so-called incidentalome play? Is it linked to the magic of evolution by coincidence in the context of the coincidentalome?
For comparison, McEwen et al., (1964) linked the creation of ATP and the creation of RNA to to the epigenetic clocks in Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
That’s not a coincidence. Clearly, many others have failed to move forward. Until more of them learn to link the creation of subatomic particles to the creation of ATP and the creation of RNA, which biophysically constrained viral latency, they cannot match what Bumbarger et al. (2013), did via their example of nutrient-dependent pheromone-controlled changes in C. elegans and sympatric speciation in a predatory nematode with teeth.
Pristionchus and other diplogastrid nematodes carry living bacteria in the gut, and they gain energy from organismic interactions during bacterial feeding
“The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding behaviours of P. pacificus and C. elegans”, Ralf Sommer concludes.
The ClinVar database of reports of the relationships among human variations and phenotypes and the HbVar database of human Hemoglobin Variants and Thalassemia Mutations collectively link what people eat to more than 1700 human hemoglobin variants via the light activated assembly of the peptide nucleic acid-microRNA nanocomplex, which prevents all virus-driven pathology in the context of Biblical Genesis and the food energy-dependent pheromone-controlled physiology of reproduction.
For example, fixation of the EDAR V370A variant in the mouse-to-human model of ecological adaptations also links the creation of achiral glycine to all morphological and behavioral phenotypes in all vertebrates with jaws.
As an example the change from Asp to His will increase the normal mass by 22 units and the reverse change will decrease the mass by the same amount.
See also: Olfaction Warps Visual Time Perception (2017)
The authors linked the creation of the sense of smell in bacteria to our visual perception of mass and energy in the context of the space-time continuum.
I don’t expect any answers to my question about the incindentalome in that context, or in the context of how microRNAs in circulating blood link the sun’s anti-entropic virucidal energy to biophysically constrained viral latency in all living genera via the food that organisms eat and the physiology of reproduction.
People like Joyner want more debate, they do not want scientific progress because they haven’t made any. All the serious scientists who have led the way to the cure for cancer will continue to do so, and people like Joyner will be left behind to contemplate the role of the incidentalome.